SOP1812 |
Catalog No.GC65887 |
SOP1812 is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2546091-70-5
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
SOP1812 is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds to quadruplex arrangements (G4s), and down-regulates several cancer gene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research of cancer[1].
SOP1812 (0-50 nM; 96 h) inhibits the proliferation of many cancer cells[1].
SOP1812 (0-800 nM; 6-24 h) shows great affinity to hTERT G4 and HuTel21 G4[1].
SOP1812 (40 nM; 6-24 h) affects Wnt/β-catenin, axon guidance, Hippo, MAPK and Rap1 pathways[1].
Cell Proliferation Assay[1]
Cell Line: | MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cell lines |
Concentration: | 0-50 nM |
Incubation Time: | 96 hours |
Result: | Showed anti-proliferation ability to MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cells with GI50 values of 1.3, 1.4, 5.9 and 2.6 nM, respectively. |
Cell Viability Assay[1]
Cell Line: | PANC-1 cells |
Concentration: | 0, 100, 400 and 800 nM |
Incubation Time: | 6 and 24 hours |
Result: | Binded to hTERT G4 and HuTel21 G4 with KD values of 4.9 and 28.4 nM, respectively. |
Cell Viability Assay[1]
Cell Line: | MIA PaCa-2 Cells |
Concentration: | 40 nM |
Incubation Time: | 6 and 24 hours |
Result: | Affected WNT5B, DVL1, AXIN and APC2 expression which includes in Wnt/β-catenin pathway and also showed effects on axon guidance, Hippo, MAPK, and Rap1 pathways. |
SOP1812 (1 mg/kg; i.v. once or twice per week for 28 days) shows anti-tumor activity in MIA PaCa-2 xenografts mice and KPC mice[1].
Animal Model: | Female athymic nude mice with MIA PaCa-2 xenografts[1] |
Dosage: | 1 mg/kg |
Administration: | Intravenous injection; 1 mg/kg once or twice per week; for 28 days |
Result: | Showed complete tumor regression and no significant tumor regrowth after day 28 on several animals. |
Animal Model: | KPC mice with PDAC symptoms[1] |
Dosage: | 1 mg/kg |
Administration: | Intravenous injection; 1 mg/kg once per week; for 3 weeks |
Result: | Significantly extended survival of KPC mice and showed a better effect than gemcitabine. |
Cas No. | 2546091-70-5 | SDF | Download SDF |
Formula | C45H57N7O6 | M.Wt | 791.98 |
Solubility | Storage | Store at -20°C | |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 1.2627 mL | 6.3133 mL | 12.6266 mL |
5 mM | 0.2525 mL | 1.2627 mL | 2.5253 mL |
10 mM | 0.1263 mL | 0.6313 mL | 1.2627 mL |
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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