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Inicio >> Signaling Pathways >> Proteases

Proteases

Proteases is a general term for a class of enzymes that hydrolyze protein peptide chains. According to the way they degrade polypeptides, they are divided into two categories: endopeptidases and telopeptidases. The former can cut the large molecular weight polypeptide chain from the middle to form prions and peptones with smaller molecular weights; the latter can be divided into carboxypeptidase and aminopeptidase, which respectively remove the peptide from the free carboxyl terminus or free amino terminus of the polypeptide one by one. Chain hydrolysis produces amino acids.

A general term for a class of enzymes that hydrolyze peptide bonds in proteins. According to the way they hydrolyze polypeptides, they can be divided into endopeptidases and exopeptidases. Endopeptidase cleaves the interior of the protein molecule to form smaller molecular weight peptones and peptones. Exopeptidase hydrolyzes peptide bonds one by one from the end of the free amino group or carboxyl group of protein molecules, and frees amino acids, the former is aminopeptidase and the latter is carboxypeptidase. Proteases can be classified into serine proteases, sulfhydryl proteases, metalloproteases and aspartic proteases according to their active centers and optimum pH. According to the optimum pH value of its reaction, it is divided into acidic protease, neutral protease and alkaline protease. The proteases used in industrial production are mainly endopeptidases.

Proteases are widely found in animal offal, plant stems and leaves, fruits and microorganisms. Microbial proteases are mainly produced by molds and bacteria, followed by yeast and actinomycetes.

Enzymes that catalyze the hydrolysis of proteins. There are many kinds, the important ones are pepsin, trypsin, cathepsin, papain and subtilisin. Proteases have strict selectivity for the reaction substrates they act on. A protease can only act on certain peptide bonds in protein molecules, such as the peptide bonds formed by the hydrolysis of basic amino acids catalyzed by trypsin. Proteases are widely distributed, mainly in the digestive tract of humans and animals, and are abundant in plants and microorganisms. Due to limited animal and plant resources, the industrial production of protease preparations is mainly prepared by fermentation of microorganisms such as Bacillus subtilis and Aspergillus terrestris.

Targets for  Proteases

Products for  Proteases

  1. Cat.No. Nombre del producto Información
  2. GC40378 5(S)-HEPE 5(S)-HEPE is produced by 5-lipoxygenase catalyzed oxidation of eicosapentaenoic acid (EPA). 5(S)-HEPE Chemical Structure
  3. GC40460 5(S)-HETE 5(S)-HETE is produced by the action of 5-LO on arachidonic acid to give 5(S)-HpETE, followed by reduction of the hydroperoxide. 5(S)-HETE Chemical Structure
  4. GC40829 5(S)-HETE lactone 5(S)-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of 5(S)-HETE. 5(S)-HETE lactone Chemical Structure
  5. GC46679 5(S)-HETE-d8 An internal standard for the quantification of 5-HETE 5(S)-HETE-d8 Chemical Structure
  6. GC42479 5(S)-HETrE 5(S)-HETrE is produced by the action of 5-LO when mead acid is the substrate. 5(S)-HETrE Chemical Structure
  7. GC41105 5(S)-HpEPE 5(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-LO on EPA. 5(S)-HpEPE Chemical Structure
  8. GC40784 5(Z),8(Z),14(Z)-Eicosatrienoic Acid 5(Z),8(Z),14(Z)-Eicosatrienoic acid is a polyunsaturated fatty acid that can be a substrate for 5-lipoxygenase (5-LO). 5(Z),8(Z),14(Z)-Eicosatrienoic Acid Chemical Structure
  9. GC40830 5,6-dehydro Arachidonic Acid 5,6-dehydro Arachidonic acid is an analog of arachidonic acid with an acetylene in the 5,6 position. 5,6-dehydro Arachidonic Acid Chemical Structure
  10. GC18542 5,6-dihydro-5-Fluorouracil

    5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil via the enzyme dihydropyrimidine dehydrogenase (DPD).

     5,6-dihydro-5-Fluorouracil Chemical Structure
  11. GC35152 5,6-Dihydro-5-methyluracil El 5,6-dihidro-5-metiluracilo (dihidrotimina), un producto de descomposiciÓn intermedio de la timina, proviene de animales o plantas. 5,6-Dihydro-5-methyluracil Chemical Structure
  12. GC33650 5,6-Dihydrouracil El 5,6-dihidrouracilo (5,6-5,6-dihidrouracilo), un metabolito de uracilo, se puede utilizar como marcador para la identificaciÓn de deficiencia de dihidropirimidina deshidrogenasa (DPD). 5,6-Dihydrouracil Chemical Structure
  13. GC33502 5,6-Dihydrouridine La 5,6-dihidrouridina es una base modificada que se encuentra en posiciones conservadas en el bucle D del ARNt en bacterias, eucariotas y algunas arqueas. 5,6-Dihydrouridine Chemical Structure
  14. GC42484 5,6-dihydroxy Indole El 5,6-dihidroxi Indol, un precursor de la melanina, tiene una actividad antibacteriana, antifúngica, antiviral y antiparasitaria de amplio espectro. 5,6-dihydroxy Indole Chemical Structure
  15. GC38286 5,6-Dimethyl-1H-benzo[d]imidazole El 5,6-dimetil-1H-benzo[d]imidazol es un metabolito endÓgeno. 5,6-Dimethyl-1H-benzo[d]imidazole Chemical Structure
  16. GC18466 5,6-epoxy-13-cis Retinoic Acid 5,6-epoxy-13-cis Retinoic acid is a metabolite of 13-cis retinoic acid. 5,6-epoxy-13-cis Retinoic Acid Chemical Structure
  17. GC35150 5,7,4'-Trimethoxyflavone La 5,7,4'-trimetoxiflavona se aísla de Kaempferia parviflora (KP), una famosa planta medicinal de Tailandia. La 5,7,4'-trimetoxiflavona induce la apoptosis, como lo demuestran los incrementos de la fase sub-G1, la fragmentación del ADN, la tinción de anexina-V/PI, la relación Bax/Bcl-xL, la activación proteolítica de la caspasa-3 y la degradación de poli (ADP-ribosa) polimerasa (PARP) proteína. La 5,7,4'-trimetoxiflavona es significativamente eficaz para inhibir la proliferación de células de cáncer gástrico humano SNU-16 de una manera dependiente de la concentración. 5,7,4'-Trimethoxyflavone Chemical Structure
  18. GN10629 5,7-dihydroxychromone 5,7-dihydroxychromone Chemical Structure
  19. GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone An active metabolite of various polyphenols 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone Chemical Structure
  20. GC38882 5-ALA benzyl ester hydrochloride El clorhidrato de éster bencÍlico de 5-ALA (clorhidrato de bencil-ALA) es un precursor de protoporfirina que se utiliza como agente de fotodetecciÓn. El clorhidrato de éster bencÍlico de 5-ALA induce la acumulaciÓn de protoporfirina IX (PPIX) en lÍneas celulares de carcinoma de colon. 5-ALA benzyl ester hydrochloride Chemical Structure
  21. GC35156 5-Amino-3H-imidazole-4-Carboxamide La 5-amino-3H-imidazol-4-carboxamida (AICA) es un precursor importante para la sÍntesis de purinas en general y de las nucleobases adenina y guanina en particular. 5-Amino-3H-imidazole-4-Carboxamide Chemical Structure
  22. GC32608 5-Amino-4-oxopentanoic acid El Ácido 5-amino-4-oxopentanoico (5-ALA) es un aminoÁcido no proteico que juega un papel limitante en la biosÍntesis del hemo. 5-Amino-4-oxopentanoic acid Chemical Structure
  23. GC45356 5-Aminolevulinic Acid (hydrochloride)   5-Aminolevulinic Acid (hydrochloride) Chemical Structure
  24. GC52413 5-Aminosalicylic Acid-d7 An internal standard for the quantification of 5-aminosalicylic acid 5-Aminosalicylic Acid-d7 Chemical Structure
  25. GC12713 5-Aminovaleric acid hydrochloride Se cree que el clorhidrato de Ácido 5-aminovalérico actÚa como un homÓlogo de metileno del Ácido gamma-aminobutÍrico (GABA) y funciona como un agonista débil de GABA. 5-Aminovaleric acid hydrochloride Chemical Structure
  26. GN10062 5-HTP 5-HTP Chemical Structure
  27. GC49655 5-hydroxy Buspirone A metabolite of buspirone 5-hydroxy Buspirone Chemical Structure
  28. GC42546 5-hydroxy Diclofenac 5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4. 5-hydroxy Diclofenac Chemical Structure
  29. GC49119 5-hydroxy Flunixin A metabolite of flunixin 5-hydroxy Flunixin Chemical Structure
  30. GC49315 5-hydroxy Indomethacin A metabolite of indomethacin 5-hydroxy Indomethacin Chemical Structure
  31. GC41312 5-hydroxy Omeprazole

    5-hydroxy Omeprazole is a major metabolite of omeprazole, an inhibitor of the gastric H+/K+-ATPase pump.

     5-hydroxy Omeprazole Chemical Structure
  32. GC42549 5-hydroxy Thiabendazole 5-hydroxy Thiabendazole (5-OH TBZ) is a major metabolite of the anthelmintic thiabendazole. 5-hydroxy Thiabendazole Chemical Structure
  33. GC12829 5-hydroxy Tryptophol El 5-hidroxi triptofol es un metabolito de la serotonina de los mamíferos que actúa como marcador del consumo agudo de alcohol. 5-hydroxy Tryptophol Chemical Structure
  34. GC60529 5-Hydroxy-2'-deoxyuridine La 5-hidroxi-2'-desoxiuridina (5-OHdU) es un importante producto de oxidaciÓn estable de la 2'-desoxicitidina. 5-Hydroxy-2'-deoxyuridine Chemical Structure
  35. GC42550 5-hydroxy-6-methoxy (S)-Duloxetine 5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine. 5-hydroxy-6-methoxy (S)-Duloxetine Chemical Structure
  36. GC30613 5-Hydroxydopamine hydrochloride La 5-hidroxidopamina es una amina natural en la orina humana. 5-Hydroxydopamine hydrochloride Chemical Structure
  37. GC33698 5-Hydroxyindole-3-acetic acid El Ácido 5-hidroxiindol-3-acético es el principal metabolito de la serotonina o metanefrinas, que puede utilizarse como biomarcador de tumores neuroendocrinos. 5-Hydroxyindole-3-acetic acid Chemical Structure
  38. GC42551 5-hydroxymethyl Tolterodine (formate) 5-hydroxymethyl Tolterodine is an active metabolite of the muscarinic acetylcholine receptor antagonists tolterodine and fesoterodine. 5-hydroxymethyl Tolterodine (formate) Chemical Structure
  39. GC30189 5-Hydroxymethyl-2-furancarboxylic acid El Ácido 5-hidroximetil-2-furancarboxÍlico es el principal metabolito del 5-hidroximetil-2-furfural (HMF) en el cuerpo y se elimina por vÍa renal. 5-Hydroxymethyl-2-furancarboxylic acid Chemical Structure
  40. GC33613 5-Hydroxymethyluracil El 5-hidroximetiluracilo es un producto del daÑo oxidativo del ADN. 5-Hydroxymethyluracil Chemical Structure
  41. GC62810 5-Hydroxytryptamine creatinine sulfate monohydrate El monohidrato de sulfato de creatinina de 5-hidroxitriptamina es un metabolito endÓgeno. 5-Hydroxytryptamine creatinine sulfate monohydrate Chemical Structure
  42. GC67951 5-Hydroxytryptophol-d4 5-Hydroxytryptophol-d4 Chemical Structure
  43. GC31997 5-Lipoxygenase-In-1 5-Lipoxigenasa-In-1 es un inhibidor de 5-Lipoxigenasa extraÍdo de la patente EP 331232 A2, tabla 4, compuesto ejemplo 4.10. 5-Lipoxygenase-In-1 Chemical Structure
  44. GC66031 5-LOX-IN-1 5-LOX-IN-1 (compuesto 2b) es un inhibidor de la 5-lipoxigenasa humana (5-LOX) con un valor IC50 de 2,3 μM. 5-LOX-IN-1 se puede utilizar para la investigaciÓn de la inflamaciÓn. 5-LOX-IN-1 Chemical Structure
  45. GC62811 5-Methoxy-5-oxopentanoic acid El Ácido 5-metoxi-5-oxopentanoico es un metabolito endÓgeno. 5-Methoxy-5-oxopentanoic acid Chemical Structure
  46. GC38058 5-Methoxy-DL-tryptophan El 5-metoxi-DL-triptÓfano es un metabolito endÓgeno. 5-Methoxy-DL-tryptophan Chemical Structure
  47. GC46078 5-Methoxyindole-3-acetic acid El Ácido 5-metoxiindol-3-acético es un metabolito de la melatonina. 5-Methoxyindole-3-acetic acid Chemical Structure
  48. GC64182 5-Methoxytryptamine hydrochloride 5-Methoxytryptamine hydrochloride Chemical Structure
  49. GC30712 5-Methoxytryptophol El 5-metoxitriptol es un indol natural presente en la glÁndula pineal. 5-Methoxytryptophol Chemical Structure
  50. GC42562 5-Methyl-2'-deoxycytidine La 5-metil-2'-desoxicitidina en el ADN monocatenario puede actuar en cis para seÑalar la metilaciÓn del ADN de novo. 5-Methyl-2'-deoxycytidine Chemical Structure
  51. GC33526 5-Methylcytidine La 5-metilcitidina es un nucleÓsido de pirimidina detectado en mÚltiples biofluidos. 5-Methylcytidine Chemical Structure
  52. GC35166 5-Methylcytosine La 5-metilcitosina es una modificaciÓn del ADN bien caracterizada y también se encuentra predominantemente en abundantes ARN no codificantes tanto en procariotas como en eucariotas. 5-Methylcytosine Chemical Structure
  53. GC34881 5-Methyltetrahydrofolic acid El Ácido 5-metiltetrahidrofÓlico (5-metil THF) es una forma biolÓgicamente activa de Ácido fÓlico. 5-Methyltetrahydrofolic acid Chemical Structure
  54. GC33514 5-Methyluridine La 5-metiluridina es un nucleÓsido metilado endÓgeno que se encuentra en los fluidos humanos. 5-Methyluridine Chemical Structure
  55. GC68228 5-Nitro-1,10-phenanthroline 5-Nitro-1,10-phenanthroline Chemical Structure
  56. GC35168 5-O-Demethylnobiletin La 5-O-Demetilnobiletina (5-Demetilnobiletina), una polimetoxiflavona aislada de Sideritis tragoriganum, es una inhibiciÓn directa de la 5-LOX (IC50=0,1 μM), sin afectar la expresiÓn de la COX-2. 5-O-Demethylnobiletin Chemical Structure
  57. GC41310 5-Octyl-α-ketoglutarate In addition to its role in the Krebs cycle, α-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes. 5-Octyl-α-ketoglutarate Chemical Structure
  58. GC40380 5-OxoETE

    5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils by a specific dehydrogenase.

     5-OxoETE Chemical Structure
  59. GC41322 5-OxoETE methyl ester 5-OxoETE methyl ester is an esterified form of the polyunsaturated keto acid 5-oxoETE. 5-OxoETE methyl ester Chemical Structure
  60. GC62814 5-Phenylvaleric acid El Ácido 5-fenilvalérico (Ácido 5-fenilpentanoico) es un Ácido pentanoico de origen bacteriano que se encuentra ocasionalmente en biofluidos humanos. 5-Phenylvaleric acid Chemical Structure
  61. GC11101 5-R-Rivaroxaban 5-R-Rivaroxaban Chemical Structure
  62. GC32410 5a-Pregnane-3,20-dione La 5a-pregnano-3,20-diona es el metabolito endÓgeno de la progesterona. 5a-Pregnane-3,20-dione Chemical Structure
  63. GC68374 5a-Pregnane-3,20-dione-d6 5a-Pregnane-3,20-dione-d6 Chemical Structure
  64. GC42586 6α-hydroxy Paclitaxel 6α-hidroxi Paclitaxel es un metabolito primario de Paclitaxel. 6α-hidroxi Paclitaxel conserva un efecto dependiente del tiempo sobre los polipéptidos transportadores de aniones orgÁnicos 1B1/SLCO1B1 (OATP1B1) con una potencia de inhibiciÓn similar a Paclitaxel, mientras que ya no mostrÓ inhibiciÓn dependiente del tiempo de OATP1B3. 6α-hidroxi Paclitaxel se puede utilizar para la investigaciÓn del cÁncer. 6α-hydroxy Paclitaxel Chemical Structure
  65. GC49676 6β-hydroxy Budesonide A metabolite of budesonide 6β-hydroxy Budesonide Chemical Structure
  66. GC45969 6β-hydroxy Eplerenone A major metabolite of eplerenone 6β-hydroxy Eplerenone Chemical Structure
  67. GC49629 6β-hydroxy Prednisolone A metabolite of prednisolone 6β-hydroxy Prednisolone Chemical Structure
  68. GC41424 6(S)-Lipoxin A4 The lipoxins are trihydroxy fatty acids containing a 7,9,11,13-conjugated tetraene. 6(S)-Lipoxin A4 Chemical Structure
  69. GC49749 6-Deoxypenciclovir An inactive metabolite of famciclovir 6-Deoxypenciclovir Chemical Structure
  70. GC41224 6-diazo-5-oxo-L-nor-Leucine

    6-Diazo-5-oxo-L-nor-Leucina (DON) es un análogo de la glutamina que inhibe las glutaminasas, un inactivador selectivo y basado en mecanismos de enzimas que utilizan glutamina[1-3].

     6-diazo-5-oxo-L-nor-Leucine Chemical Structure
  71. GC42578 6-Formylpterin Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen. 6-Formylpterin Chemical Structure
  72. GC18632 6-hydroxy Bexarotene 6-hydroxy Bexarotene is an oxidative metabolite of bexarotene , a high-affinity ligand for retinoid X receptors (RXRs). 6-hydroxy Bexarotene Chemical Structure
  73. GC42580 6-hydroxy Chlorzoxazone

    6-hydroxy Chlorzoxazone is a metabolite of chlorzoxazone.

     6-hydroxy Chlorzoxazone Chemical Structure
  74. GC18219 6-hydroxy Warfarin 6-hydroxy Warfarin is a metabolite of (+)-warfarin , which is a weaker vitamin K antagonist than (-)-warfarin . 6-hydroxy Warfarin Chemical Structure
  75. GC67988 6-Hydroxybenzbromarone 6-Hydroxybenzbromarone Chemical Structure
  76. GC33704 6-Hydroxymelatonin La 6-hidroximelatonina es un metabÓlico primario de la melatonina, que es metabolizada por el citocromo P450 (CYP) 1A2. 6-Hydroxymelatonin Chemical Structure
  77. GC38278 6-Hydroxynicotinic acid 6-Hydroxynicotinic acid Chemical Structure
  78. GC10067 6-Hydroxynicotinic acid El Ácido 6-hidroxinicotÍnico es un metabolito endÓgeno. 6-Hydroxynicotinic acid Chemical Structure
  79. GC62816 6-Hydroxypyridin-2(1H)-one hydrochloride El clorhidrato de 6-hidroxipiridin-2(1H)-ona es un metabolito endÓgeno. 6-Hydroxypyridin-2(1H)-one hydrochloride Chemical Structure
  80. GC49235 6-Methylmercaptopurine A metabolite of 6-mercaptopurine 6-Methylmercaptopurine Chemical Structure
  81. GC49488 6-Methylmercaptopurine-d3 An internal standard for the quantification of 6-MMP 6-Methylmercaptopurine-d3 Chemical Structure
  82. GC64741 6-Methylnicotinamide La 6-metilnicotinamida, un derivado de la nicotinamida, es un metabolito endÓgeno. 6-Methylnicotinamide Chemical Structure
  83. GC48721 6-O-Demethyl Griseofulvin A metabolite of griseofulvin 6-O-Demethyl Griseofulvin Chemical Structure
  84. GC42584 6-O-desmethyl Donepezil 6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil. 6-O-desmethyl Donepezil Chemical Structure
  85. GC65015 6-Phosphogluconic acid trisodium El Ácido 6-fosfoglucÓnico trisÓdico es un inhibidor potente y competitivo de la fosfoglucosa isomerasa (PGI) con Kis de 48 μM para glucosa 6-fosfato y 42 μM para fructosa 6-fosfato. 6-Phosphogluconic acid trisodium Chemical Structure
  86. GC50613 673 A ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC) 673 A Chemical Structure
  87. GC18335 6β-hydroxy Dexamethasone 6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. 6β-hydroxy Dexamethasone Chemical Structure
  88. GC40087 7α-hydroxy-4-Cholesten-3-one 7α-hidroxi-4-colesten-3-ona es un intermediario en la sÍntesis de Ácidos biliares a partir del colesterol. 7α-hydroxy-4-Cholesten-3-one Chemical Structure
  89. GC49298 7α-Thiomethylspironolactone A major metabolite of spironolactone 7α-Thiomethylspironolactone Chemical Structure
  90. GC49391 7α-Thiospironolactone An active metabolite of spironolactone 7α-Thiospironolactone Chemical Structure
  91. GC46732 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid A metabolite of DPA with antiinflammatory properties 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid Chemical Structure
  92. GC10533 7,8-dihydro-L-Biopterin La 7,8-dihidro-L-biopterina es un producto de oxidaciÓn de la tetrahidrobiopterina. 7,8-dihydro-L-Biopterin Chemical Structure
  93. GC45673 7,8-Dihydroneopterin La 7,8-dihidroneopterina, un marcador de inflamaciÓn, induce la apoptosis celular en astrocitos y neuronas a través de la mejora de la expresiÓn de Óxido nÍtrico sintasa (iNOS). 7,8-Dihydroneopterin Chemical Structure
  94. GC33450 7-Dehydrocholesterol El 7-dehidrocolesterol es un precursor biosintético del colesterol y la vitamina D3. 7-Dehydrocholesterol Chemical Structure
  95. GC40978 7-epi Maresin 1 7-epi Maresin 1 is the inactive 7(S) epimer of Maresin 1, which contains a 7(R) hydroxyl group. 7-epi Maresin 1 Chemical Structure
  96. GC48649 7-hydroxy Chlorpromazine (hydrochloride) An active metabolite of chlorpromazine 7-hydroxy Chlorpromazine (hydrochloride) Chemical Structure
  97. GC42606 7-hydroxy Coumarin Glucuronide (sodium salt) 7-hydroxy Coumarin glucuronide is a 7-hydroxy coumarin phase II metabolite that can be used as a standard for the analysis of 7-hydroxy coumarin metabolism. 7-hydroxy Coumarin Glucuronide (sodium salt) Chemical Structure
  98. GC42607 7-hydroxy Coumarin sulfate (potassium salt) 7-hydroxy Coumarin sulfate is a phase II metabolite of coumarin that can be used as an internal standard for the analysis of 7-hydroxy coumarin metabolism using GC- or LC-MS. 7-hydroxy Coumarin sulfate (potassium salt) Chemical Structure
  99. GC49748 7-hydroxy Etodolac An inactive metabolite of etodolac 7-hydroxy Etodolac Chemical Structure
  100. GC49051 7-hydroxy Methotrexate El 7-hidroxi metotrexato es un metabolito principal del metotrexato 7-hydroxy Methotrexate Chemical Structure
  101. GC42608 7-hydroxy Methotrexate (sodium salt)

    7-hydroxy Methotrexate (7-hydroxy MTX) is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases.

     7-hydroxy Methotrexate (sodium salt) Chemical Structure

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