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Accueil >> Signaling Pathways >> Proteases

Proteases

Proteases is a general term for a class of enzymes that hydrolyze protein peptide chains. According to the way they degrade polypeptides, they are divided into two categories: endopeptidases and telopeptidases. The former can cut the large molecular weight polypeptide chain from the middle to form prions and peptones with smaller molecular weights; the latter can be divided into carboxypeptidase and aminopeptidase, which respectively remove the peptide from the free carboxyl terminus or free amino terminus of the polypeptide one by one. Chain hydrolysis produces amino acids.

A general term for a class of enzymes that hydrolyze peptide bonds in proteins. According to the way they hydrolyze polypeptides, they can be divided into endopeptidases and exopeptidases. Endopeptidase cleaves the interior of the protein molecule to form smaller molecular weight peptones and peptones. Exopeptidase hydrolyzes peptide bonds one by one from the end of the free amino group or carboxyl group of protein molecules, and frees amino acids, the former is aminopeptidase and the latter is carboxypeptidase. Proteases can be classified into serine proteases, sulfhydryl proteases, metalloproteases and aspartic proteases according to their active centers and optimum pH. According to the optimum pH value of its reaction, it is divided into acidic protease, neutral protease and alkaline protease. The proteases used in industrial production are mainly endopeptidases.

Proteases are widely found in animal offal, plant stems and leaves, fruits and microorganisms. Microbial proteases are mainly produced by molds and bacteria, followed by yeast and actinomycetes.

Enzymes that catalyze the hydrolysis of proteins. There are many kinds, the important ones are pepsin, trypsin, cathepsin, papain and subtilisin. Proteases have strict selectivity for the reaction substrates they act on. A protease can only act on certain peptide bonds in protein molecules, such as the peptide bonds formed by the hydrolysis of basic amino acids catalyzed by trypsin. Proteases are widely distributed, mainly in the digestive tract of humans and animals, and are abundant in plants and microorganisms. Due to limited animal and plant resources, the industrial production of protease preparations is mainly prepared by fermentation of microorganisms such as Bacillus subtilis and Aspergillus terrestris.

Targets for  Proteases

Products for  Proteases

  1. Cat.No. Nom du produit Informations
  2. GC40378 5(S)-HEPE 5(S)-HEPE is produced by 5-lipoxygenase catalyzed oxidation of eicosapentaenoic acid (EPA). 5(S)-HEPE Chemical Structure
  3. GC40460 5(S)-HETE 5(S)-HETE is produced by the action of 5-LO on arachidonic acid to give 5(S)-HpETE, followed by reduction of the hydroperoxide. 5(S)-HETE Chemical Structure
  4. GC40829 5(S)-HETE lactone 5(S)-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of 5(S)-HETE. 5(S)-HETE lactone Chemical Structure
  5. GC46679 5(S)-HETE-d8 An internal standard for the quantification of 5-HETE 5(S)-HETE-d8 Chemical Structure
  6. GC42479 5(S)-HETrE 5(S)-HETrE is produced by the action of 5-LO when mead acid is the substrate. 5(S)-HETrE Chemical Structure
  7. GC41105 5(S)-HpEPE 5(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-LO on EPA. 5(S)-HpEPE Chemical Structure
  8. GC40784 5(Z),8(Z),14(Z)-Eicosatrienoic Acid 5(Z),8(Z),14(Z)-Eicosatrienoic acid is a polyunsaturated fatty acid that can be a substrate for 5-lipoxygenase (5-LO). 5(Z),8(Z),14(Z)-Eicosatrienoic Acid Chemical Structure
  9. GC40830 5,6-dehydro Arachidonic Acid 5,6-dehydro Arachidonic acid is an analog of arachidonic acid with an acetylene in the 5,6 position. 5,6-dehydro Arachidonic Acid Chemical Structure
  10. GC18542 5,6-dihydro-5-Fluorouracil

    5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil via the enzyme dihydropyrimidine dehydrogenase (DPD).

     5,6-dihydro-5-Fluorouracil Chemical Structure
  11. GC35152 5,6-Dihydro-5-methyluracil Le 5,6-dihydro-5-méthyluracile (dihydrothymine), un produit de dégradation intermédiaire de la thymine, provient d'animaux ou de plantes. 5,6-Dihydro-5-methyluracil Chemical Structure
  12. GC33650 5,6-Dihydrouracil Le 5,6-dihydrouracile (5,6-5,6-dihydrouracile), un métabolite de l'uracile, peut être utilisé comme marqueur pour l'identification de la dihydropyrimidine déshydrogénase (DPD) déficiente. 5,6-Dihydrouracil Chemical Structure
  13. GC33502 5,6-Dihydrouridine La 5,6-dihydrouridine est une base modifiée trouvée dans des positions conservées dans la boucle D de l'ARNt chez les bactéries, les eucaryotes et certaines archées. 5,6-Dihydrouridine Chemical Structure
  14. GC42484 5,6-dihydroxy Indole Le 5,6-dihydroxy indole, précurseur de la mélanine, possède une activité antibactérienne, antifongique, antivirale, antiparasitaire à large spectre. 5,6-dihydroxy Indole Chemical Structure
  15. GC38286 5,6-Dimethyl-1H-benzo[d]imidazole Le 5,6-diméthyl-1H-benzo[d]imidazole est un métabolite endogène. 5,6-Dimethyl-1H-benzo[d]imidazole Chemical Structure
  16. GC18466 5,6-epoxy-13-cis Retinoic Acid 5,6-epoxy-13-cis Retinoic acid is a metabolite of 13-cis retinoic acid. 5,6-epoxy-13-cis Retinoic Acid Chemical Structure
  17. GC35150 5,7,4'-Trimethoxyflavone La 5,7,4'-triméthoxyflavone est isolée de Kaempferia parviflora (KP) qui est une célèbre plante médicinale de Thaïlande. La 5,7,4'-triméthoxyflavone induit l'apoptose, comme en témoignent les augmentations de la phase sous-G1, la fragmentation de l'ADN, la coloration annexine-V/PI, le rapport Bax/Bcl-xL, l'activation protéolytique de la caspase-3 et la dégradation de la poly (ADP-ribose) polymérase (PARP). La 5,7,4'-triméthoxyflavone est significativement efficace pour inhiber la prolifération des cellules cancéreuses gastriques humaines SNU-16 d'une manière dépendante de la concentration. 5,7,4'-Trimethoxyflavone Chemical Structure
  18. GN10629 5,7-dihydroxychromone 5,7-dihydroxychromone Chemical Structure
  19. GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone An active metabolite of various polyphenols 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone Chemical Structure
  20. GC38882 5-ALA benzyl ester hydrochloride Le chlorhydrate d'ester benzylique de 5-ALA (chlorhydrate de Benzyl-ALA) est un précurseur de la protoporphyrine utilisé comme agent de photodétection. Le chlorhydrate d'ester benzylique de 5-ALA induit une accumulation de protoporphyrine IX (PPIX) dans les lignées cellulaires de carcinome du cÔlon. 5-ALA benzyl ester hydrochloride Chemical Structure
  21. GC35156 5-Amino-3H-imidazole-4-Carboxamide Le 5-Amino-3H-imidazole-4-Carboxamide (AICA) est un précurseur important pour la synthèse des purines en général et des nucléobases adénine et guanine en particulier. 5-Amino-3H-imidazole-4-Carboxamide Chemical Structure
  22. GC32608 5-Amino-4-oxopentanoic acid L'acide 5-amino-4-oxopentanoÏque (5-ALA) est un acide aminé non protéique qui joue un rÔle limitant dans la biosynthèse de l'hème. 5-Amino-4-oxopentanoic acid Chemical Structure
  23. GC45356 5-Aminolevulinic Acid (hydrochloride)   5-Aminolevulinic Acid (hydrochloride) Chemical Structure
  24. GC52413 5-Aminosalicylic Acid-d7 An internal standard for the quantification of 5-aminosalicylic acid 5-Aminosalicylic Acid-d7 Chemical Structure
  25. GC12713 5-Aminovaleric acid hydrochloride On pense que le chlorhydrate d'acide 5-aminovalérique agit comme un homologue méthylène de l'acide gamma-aminobutyrique (GABA) et fonctionne comme un agoniste faible du GABA. 5-Aminovaleric acid hydrochloride Chemical Structure
  26. GN10062 5-HTP 5-HTP Chemical Structure
  27. GC49655 5-hydroxy Buspirone A metabolite of buspirone 5-hydroxy Buspirone Chemical Structure
  28. GC42546 5-hydroxy Diclofenac 5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4. 5-hydroxy Diclofenac Chemical Structure
  29. GC49119 5-hydroxy Flunixin A metabolite of flunixin 5-hydroxy Flunixin Chemical Structure
  30. GC49315 5-hydroxy Indomethacin A metabolite of indomethacin 5-hydroxy Indomethacin Chemical Structure
  31. GC41312 5-hydroxy Omeprazole

    5-hydroxy Omeprazole is a major metabolite of omeprazole, an inhibitor of the gastric H+/K+-ATPase pump.

     5-hydroxy Omeprazole Chemical Structure
  32. GC42549 5-hydroxy Thiabendazole 5-hydroxy Thiabendazole (5-OH TBZ) is a major metabolite of the anthelmintic thiabendazole. 5-hydroxy Thiabendazole Chemical Structure
  33. GC12829 5-hydroxy Tryptophol Le 5-hydroxy tryptophol est un métabolite de la sérotonine chez les mammifères, agissant comme un marqueur de la consommation aiguë d'alcool. 5-hydroxy Tryptophol Chemical Structure
  34. GC60529 5-Hydroxy-2'-deoxyuridine La 5-hydroxy-2'-désoxyuridine (5-OHdU) est un produit d'oxydation stable majeur de la 2'-désoxycytidine. 5-Hydroxy-2'-deoxyuridine Chemical Structure
  35. GC42550 5-hydroxy-6-methoxy (S)-Duloxetine 5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine. 5-hydroxy-6-methoxy (S)-Duloxetine Chemical Structure
  36. GC30613 5-Hydroxydopamine hydrochloride La 5-hydroxydopamine est une amine naturellement présente dans l'urine humaine. 5-Hydroxydopamine hydrochloride Chemical Structure
  37. GC33698 5-Hydroxyindole-3-acetic acid L'acide 5-hydroxyindole-3-acétique est le principal métabolite de la sérotonine ou métanéphrines, qui peut être utilisé comme biomarqueur des tumeurs neuroendocrines. 5-Hydroxyindole-3-acetic acid Chemical Structure
  38. GC42551 5-hydroxymethyl Tolterodine (formate) 5-hydroxymethyl Tolterodine is an active metabolite of the muscarinic acetylcholine receptor antagonists tolterodine and fesoterodine. 5-hydroxymethyl Tolterodine (formate) Chemical Structure
  39. GC30189 5-Hydroxymethyl-2-furancarboxylic acid L'acide 5-hydroxyméthyl-2-furancarboxylique est le principal métabolite du 5-hydroxyméthyl-2-furfural (HMF) dans l'organisme et éliminé par les reins. 5-Hydroxymethyl-2-furancarboxylic acid Chemical Structure
  40. GC33613 5-Hydroxymethyluracil Le 5-hydroxyméthyluracile est un produit de dommages oxydatifs À l'ADN. 5-Hydroxymethyluracil Chemical Structure
  41. GC62810 5-Hydroxytryptamine creatinine sulfate monohydrate Le monohydrate de sulfate de créatinine de 5-hydroxytryptamine est un métabolite endogène. 5-Hydroxytryptamine creatinine sulfate monohydrate Chemical Structure
  42. GC67951 5-Hydroxytryptophol-d4 5-Hydroxytryptophol-d4 Chemical Structure
  43. GC31997 5-Lipoxygenase-In-1 La 5-Lipoxygénase-In-1 est un inhibiteur de la 5-Lipoxygénase extrait du brevet EP 331232 A2, tableau 4, exemple composé 4.10. 5-Lipoxygenase-In-1 Chemical Structure
  44. GC66031 5-LOX-IN-1 5-LOX-IN-1 (composé 2b) est un inhibiteur de la 5-lipoxygénase humaine (5-LOX) avec une valeur IC50 de 2,3 μM. 5-LOX-IN-1 peut être utilisé pour la recherche de l'inflammation. 5-LOX-IN-1 Chemical Structure
  45. GC62811 5-Methoxy-5-oxopentanoic acid L'acide 5-méthoxy-5-oxopentanoÏque est un métabolite endogène. 5-Methoxy-5-oxopentanoic acid Chemical Structure
  46. GC38058 5-Methoxy-DL-tryptophan Le 5-méthoxy-DL-tryptophane est un métabolite endogène. 5-Methoxy-DL-tryptophan Chemical Structure
  47. GC46078 5-Methoxyindole-3-acetic acid L'acide 5-méthoxyindole-3-acétique est un métabolite de la mélatonine. 5-Methoxyindole-3-acetic acid Chemical Structure
  48. GC64182 5-Methoxytryptamine hydrochloride 5-Methoxytryptamine hydrochloride Chemical Structure
  49. GC30712 5-Methoxytryptophol Le 5-méthoxytryptophol est un indole naturel présent dans la glande pinéale. 5-Methoxytryptophol Chemical Structure
  50. GC42562 5-Methyl-2'-deoxycytidine La 5-méthyl-2'-désoxycytidine dans l'ADN simple brin peut agir en cis pour signaler la méthylation de novo de l'ADN . 5-Methyl-2'-deoxycytidine Chemical Structure
  51. GC33526 5-Methylcytidine La 5-méthylcytidine est un nucléoside pyrimidique détecté dans plusieurs biofluides. 5-Methylcytidine Chemical Structure
  52. GC35166 5-Methylcytosine La 5-méthylcytosine est une modification de l'ADN bien caractérisée et se trouve également principalement dans les ARN non codants abondants chez les procaryotes et les eucaryotes. 5-Methylcytosine Chemical Structure
  53. GC34881 5-Methyltetrahydrofolic acid L'acide 5-méthyltétrahydrofolique (5-méthyl THF) est une forme biologiquement active de l'acide folique. 5-Methyltetrahydrofolic acid Chemical Structure
  54. GC33514 5-Methyluridine La 5-méthyluridine est un nucléoside méthylé endogène présent dans les fluides humains. 5-Methyluridine Chemical Structure
  55. GC68228 5-Nitro-1,10-phenanthroline 5-Nitro-1,10-phenanthroline Chemical Structure
  56. GC35168 5-O-Demethylnobiletin La 5-O-déméthylnobilétine (5-déméthylnobilétine), une polyméthoxyflavone isolée de Sideritis tragoriganum, est une inhibition directe de la 5-LOX (IC50 = 0,1 μM), sans affecter l'expression de la COX-2. 5-O-Demethylnobiletin Chemical Structure
  57. GC41310 5-Octyl-α-ketoglutarate In addition to its role in the Krebs cycle, α-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes. 5-Octyl-α-ketoglutarate Chemical Structure
  58. GC40380 5-OxoETE

    5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils by a specific dehydrogenase.

     5-OxoETE Chemical Structure
  59. GC41322 5-OxoETE methyl ester 5-OxoETE methyl ester is an esterified form of the polyunsaturated keto acid 5-oxoETE. 5-OxoETE methyl ester Chemical Structure
  60. GC62814 5-Phenylvaleric acid L'acide 5-phénylvalérique (acide 5-phénylpentanoÏque) est un acide pentanoÏque d'origine bactérienne, parfois présent dans les biofluides humains. 5-Phenylvaleric acid Chemical Structure
  61. GC11101 5-R-Rivaroxaban 5-R-Rivaroxaban Chemical Structure
  62. GC32410 5a-Pregnane-3,20-dione La 5a-prégnane-3,20-dione est le métabolite endogène de la progestérone. 5a-Pregnane-3,20-dione Chemical Structure
  63. GC68374 5a-Pregnane-3,20-dione-d6 5a-Pregnane-3,20-dione-d6 Chemical Structure
  64. GC42586 6α-hydroxy Paclitaxel 6α-hydroxy Paclitaxel est un métabolite primaire du Paclitaxel. 6α-hydroxy Le paclitaxel conserve un effet dépendant du temps sur les polypeptides transporteurs d'anions organiques 1B1/SLCO1B1 (OATP1B1) avec une puissance d'inhibition similaire À celle du paclitaxel, alors qu'il n'a plus montré d'inhibition dépendante du temps de l'OATP1B3. 6α-hydroxy Paclitaxel peut être utilisé pour la recherche sur le cancer. 6α-hydroxy Paclitaxel Chemical Structure
  65. GC49676 6β-hydroxy Budesonide A metabolite of budesonide 6β-hydroxy Budesonide Chemical Structure
  66. GC45969 6β-hydroxy Eplerenone A major metabolite of eplerenone 6β-hydroxy Eplerenone Chemical Structure
  67. GC49629 6β-hydroxy Prednisolone A metabolite of prednisolone 6β-hydroxy Prednisolone Chemical Structure
  68. GC41424 6(S)-Lipoxin A4 The lipoxins are trihydroxy fatty acids containing a 7,9,11,13-conjugated tetraene. 6(S)-Lipoxin A4 Chemical Structure
  69. GC49749 6-Deoxypenciclovir An inactive metabolite of famciclovir 6-Deoxypenciclovir Chemical Structure
  70. GC41224 6-diazo-5-oxo-L-nor-Leucine

    La 6-Diazo-5-oxo-L-nor-Leucine (DON) est un analogue de la glutamine qui inhibe les glutaminases, un inactivateur sélectif et basé sur le mécanisme des enzymes utilisant la glutamine[1-3].

     6-diazo-5-oxo-L-nor-Leucine Chemical Structure
  71. GC42578 6-Formylpterin Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen. 6-Formylpterin Chemical Structure
  72. GC18632 6-hydroxy Bexarotene 6-hydroxy Bexarotene is an oxidative metabolite of bexarotene , a high-affinity ligand for retinoid X receptors (RXRs). 6-hydroxy Bexarotene Chemical Structure
  73. GC42580 6-hydroxy Chlorzoxazone

    6-hydroxy Chlorzoxazone is a metabolite of chlorzoxazone.

     6-hydroxy Chlorzoxazone Chemical Structure
  74. GC18219 6-hydroxy Warfarin 6-hydroxy Warfarin is a metabolite of (+)-warfarin , which is a weaker vitamin K antagonist than (-)-warfarin . 6-hydroxy Warfarin Chemical Structure
  75. GC67988 6-Hydroxybenzbromarone 6-Hydroxybenzbromarone Chemical Structure
  76. GC33704 6-Hydroxymelatonin La 6-hydroxymélatonine est un métabolisme primaire de la mélatonine, qui est métabolisée par le cytochrome P450 (CYP) 1A2. 6-Hydroxymelatonin Chemical Structure
  77. GC38278 6-Hydroxynicotinic acid 6-Hydroxynicotinic acid Chemical Structure
  78. GC10067 6-Hydroxynicotinic acid L'acide 6-hydroxynicotinique est un métabolite endogène. 6-Hydroxynicotinic acid Chemical Structure
  79. GC62816 6-Hydroxypyridin-2(1H)-one hydrochloride Le chlorhydrate de 6-hydroxypyridin-2(1H)-one est un métabolite endogène. 6-Hydroxypyridin-2(1H)-one hydrochloride Chemical Structure
  80. GC49235 6-Methylmercaptopurine A metabolite of 6-mercaptopurine 6-Methylmercaptopurine Chemical Structure
  81. GC49488 6-Methylmercaptopurine-d3 An internal standard for the quantification of 6-MMP 6-Methylmercaptopurine-d3 Chemical Structure
  82. GC64741 6-Methylnicotinamide Le 6-méthylnicotinamide, un dérivé du nicotinamide, est un métabolite endogène. 6-Methylnicotinamide Chemical Structure
  83. GC48721 6-O-Demethyl Griseofulvin A metabolite of griseofulvin 6-O-Demethyl Griseofulvin Chemical Structure
  84. GC42584 6-O-desmethyl Donepezil 6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil. 6-O-desmethyl Donepezil Chemical Structure
  85. GC65015 6-Phosphogluconic acid trisodium L'acide 6-phosphogluconique trisodique est un inhibiteur puissant et compétitif de la phosphoglucose isomérase (PGI) avec un Kis de 48 μM pour le glucose 6-phosphate et de 42 μM pour le fructose 6-phosphate. 6-Phosphogluconic acid trisodium Chemical Structure
  86. GC50613 673 A ALDH1A inhibitor; depletes CD133+ cancer stem cells (CSC) 673 A Chemical Structure
  87. GC18335 6β-hydroxy Dexamethasone 6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. 6β-hydroxy Dexamethasone Chemical Structure
  88. GC40087 7α-hydroxy-4-Cholesten-3-one 7α-hydroxy-4-cholesten-3-one est un intermédiaire dans la synthèse des acides biliaires À partir du cholestérol. 7α-hydroxy-4-Cholesten-3-one Chemical Structure
  89. GC49298 7α-Thiomethylspironolactone A major metabolite of spironolactone 7α-Thiomethylspironolactone Chemical Structure
  90. GC49391 7α-Thiospironolactone An active metabolite of spironolactone 7α-Thiospironolactone Chemical Structure
  91. GC46732 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid A metabolite of DPA with antiinflammatory properties 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid Chemical Structure
  92. GC10533 7,8-dihydro-L-Biopterin La 7,8-dihydro-L-bioptérine est un produit d'oxydation de la tétrahydrobioptérine. 7,8-dihydro-L-Biopterin Chemical Structure
  93. GC45673 7,8-Dihydroneopterin La 7,8-dihydronéoptérine, un marqueur de l'inflammation, induit l'apoptose cellulaire dans les astrocytes et les neurones via l'amélioration de l'expression de l'oxyde nitrique synthase (iNOS). 7,8-Dihydroneopterin Chemical Structure
  94. GC33450 7-Dehydrocholesterol Le 7-déhydrocholestérol est un précurseur biosynthétique du cholestérol et de la vitamine D3. 7-Dehydrocholesterol Chemical Structure
  95. GC40978 7-epi Maresin 1 7-epi Maresin 1 is the inactive 7(S) epimer of Maresin 1, which contains a 7(R) hydroxyl group. 7-epi Maresin 1 Chemical Structure
  96. GC48649 7-hydroxy Chlorpromazine (hydrochloride) An active metabolite of chlorpromazine 7-hydroxy Chlorpromazine (hydrochloride) Chemical Structure
  97. GC42606 7-hydroxy Coumarin Glucuronide (sodium salt) 7-hydroxy Coumarin glucuronide is a 7-hydroxy coumarin phase II metabolite that can be used as a standard for the analysis of 7-hydroxy coumarin metabolism. 7-hydroxy Coumarin Glucuronide (sodium salt) Chemical Structure
  98. GC42607 7-hydroxy Coumarin sulfate (potassium salt) 7-hydroxy Coumarin sulfate is a phase II metabolite of coumarin that can be used as an internal standard for the analysis of 7-hydroxy coumarin metabolism using GC- or LC-MS. 7-hydroxy Coumarin sulfate (potassium salt) Chemical Structure
  99. GC49748 7-hydroxy Etodolac An inactive metabolite of etodolac 7-hydroxy Etodolac Chemical Structure
  100. GC49051 7-hydroxy Methotrexate Le 7-hydroxy méthotrexate est un métabolite majeur du méthotrexate 7-hydroxy Methotrexate Chemical Structure
  101. GC42608 7-hydroxy Methotrexate (sodium salt)

    7-hydroxy Methotrexate (7-hydroxy MTX) is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases.

     7-hydroxy Methotrexate (sodium salt) Chemical Structure

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