Stearoyl-L-carnitine-d3 (chloride) (Synonyms: CAR 18:0-d3, C18:0 Carnitine-d3, L-Carnitine octdecanoyl ester-d3, L-Carnitine stearoyl ester-d3, L-Octadecanoylcarnitine-d3, Octadecanoyl-L-carnitine-d3, L-Stearoylcarnitine-d3, R-Stearoyl carnitine-d3)

Stearoyl-L-carnitine-d₃ (chloride) is intended for use as an internal standard for the quantification of stearoyl-L-carnitine by GC- or LC-MS. Stearoyl-L-carnitine is a naturally occurring long-chain acylcarnitine.¹ It inhibits sodium-dependent [³H]carnitine uptake in human proximal convoluted tubular (HPCT) cells by 52% when used at a concentration of 500 μM.² It also inhibits lecithin:cholesterol acyltransferase activity in rat, but not human, plasma when used at a concentration of 500 µM.³ Plasma levels of stearoyl-L-carnitine are decreased in patients with chronic fatigue syndrome and increased in patients with end-stage renal disease.^4,1

1.Reuter, S.E., Evans, A.M., Faull, R.J., et al.Impact of haemodialysis on individual endogenous plasma acylcarnitine concentrations in end-stage renal diseaseAnn. Clin. Biochem.42(Pt 5)387-393(2005) 2.Huang, W., Shaikh, S.N., Ganapathy, M.E., et al.Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cellsBiochem. Pharmacol.58(8)1361-1370(1999) 3.Bell, F.P.Carnitine esters: Novel inhibitors of plasma lecithin: Cholesterol acyltransferase in experimental animals but not in man (Homo sapiens)Int. J. Biochem.15(2)133-136(1983) 4.Reuter, S.E., and Evans, A.M.Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activityJ. Intern. Med.270(1)76-84(2011)