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Tetrahydro-11-deoxy Cortisol (Synonyms: NSC 53901, 5β-Pregnane-3α,17α,21-triol-20-one, Tetrahydrodeoxycortisol, THS)

Catalog No.GC40341

Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol.

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Tetrahydro-11-deoxy Cortisol Chemical Structure

Cas No.: 68-60-0

Size Price Stock Qty
10mg
$94.00
In stock
50mg
$377.00
In stock
100mg
$659.00
In stock
250mg
$942.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Description of Tetrahydro-11-deoxy Cortisol

Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA.

Chemical Properties of Tetrahydro-11-deoxy Cortisol

Cas No. 68-60-0 SDF
Synonyms NSC 53901, 5β-Pregnane-3α,17α,21-triol-20-one, Tetrahydrodeoxycortisol, THS
Canonical SMILES O[C@@H]1CC[C@@]2(C)[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)([H])C1
Formula C21H34O4 M.Wt 350.5
Solubility DMF: 30 mg/mL,DMSO: 30 mg/mL,Ethanol: 30 mg/mL,Ethanol:PBS(pH 7.2) (1:1): 0.2 mg/mL Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Tetrahydro-11-deoxy Cortisol

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1 mg 5 mg 10 mg
1 mM 2.8531 mL 14.2653 mL 28.5307 mL
5 mM 0.5706 mL 2.8531 mL 5.7061 mL
10 mM 0.2853 mL 1.4265 mL 2.8531 mL
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In vivo Formulation Calculator (Clear solution) of Tetrahydro-11-deoxy Cortisol

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 19 reference(s) in Google Scholar.)

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