tetranor-PGDM-d6 (Synonyms: tetranorProstaglandin D Metabolited6)

tetranor-PGDM-d₆ contains six deuterium atoms at the 17, 17', 18, 18', 19 and 19' positions. It is intended for use as an internal standard for the quantification of tetranor-PGDM by GC- or LC-mass spectrometry (MS). Prostaglandin D₂ (PGD₂) is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.¹ PGD₂ is also produced in the brain by lipocalin PGD-synthase also known as β-trace.^2,3 In the brain, PGD₂ produces normal physiological sleep and lowering of body temperature.^2,3 Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.⁴ tetranor-PGDM is a major metabolite of PGD₂ that is detectable in human and murine urine.⁵ The levels of tetranor-PGDM and 2,3-dinor-11b-PGF_2α, a related PGD₂ metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively. tetranor-PGDM was detected in mouse urine at a level of 8.1 ± 1.3 ng/mg creatinine.⁵

1.Roberts, L.J., II, and Sweetman, B.J.Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosisProstaglandins30(3)383-400(1985) 2.Hayaishi, O.Sleep-wake regulation by prostaglandins D2 and E2J. Biol. Chem.263(29)14593-14596(1988) 3.Onoe, H., Ueno, R., Fujita, I., et al.Prostaglandin D2, a cerebral sleep-inducing substance in monkeysProc. Natl. Acad. Sci. U.S.A.85(11)4082-4086(1988) 4.Giles, H., and Leff, P.The biology and pharmacology of PGD2Prostaglandins35(2)277-300(1988) 5.Song, W.L., Wang, M., Ricciotti, E., et al.Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humansJ. Biol. Chem.283(2)1179-1188(2008)