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THR-123 TFA

Catalog No.GC81350 Copy One-Click Copy Product Info

THR-123 TFA is an orally active ALK3 peptide agonist.

Products are for research use only. Not for human use. We do not sell to patients.

THR-123 TFA Chemical Structure

Size Price Stock Qty
5mg
$85.00
In stock
10mg
$138.00
In stock
25mg
$243.00
In stock
50mg
$365.00
In stock

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Sample solution is provided at 25 µL, 10mM.



Description of THR-123 TFA

THR-123 TFA is an orally active ALK3 peptide agonist. THR-123 TFA has a relatively weak binding to ALK2, but does not bind to ALK6. THR-123 TFA suppresses inflammation, Apoptosis and the epithelial-to-mesenchymal transition program and reverses established fibrosis in five mouse models of acute and chronic renal injury. THR-123 TFA can be used for the study of kidney fibrosis [1].

References:
[1]. Sugimoto H, et al. Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nat Med. 2012 Feb 5;18(3):396-404.

Chemical Properties of THR-123 TFA

Cas No. SDF
Formula C83H124N22O27S2·xC2HF3O2 M.Wt 1926.13
Solubility DMSO: 100 mg/mL (Need ultrasonic) Storage Sealed storage, away from moisture
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of THR-123 TFA

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1 mg 5 mg 10 mg
1 mM 519.2 μL 2.5959 mL 5.1918 mL
5 mM 103.8 μL 519.2 μL 1.0384 mL
10 mM 51.9 μL 259.6 μL 519.2 μL
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In vivo Formulation Calculator (Clear solution) of THR-123 TFA

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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