Tolnaftate (Synonyms: NSC 233648, SCH 10144) |
| Catalog No.GC10337 |
anti-fungal agent
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2398-96-1
Sample solution is provided at 25 µL, 10mM.
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Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent. .
Tolnaftate (NP-27) blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans[1]. Tolnaftate (NP-27) inhibited sterol biosynthesis, At 100 microM, tolnaftate caused up to a 30% release of intracellular [14C]aminoisobutyric acid[2].
References:
[1]. Ryder, N.S., I. Frank, and M.C. Dupont, Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother, 1986. 29(5): p. 858-60.
[2]. Georgopapadakou, N.H. and A. Bertasso, Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother, 1992. 36(8): p. 1779-81.
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