Home>>Signaling Pathways>> Immunology/Inflammation>>transferrin fragment

transferrin fragment (Synonyms: H2N-Ala-Asp-Arg-Asp-Gln-Tyr-Glu-Leu-Leu-Cys-Leu-Asp-Asn-Thr-Arg-OH )

Catalog No.GP10064

Products are for research use only. Not for human use. We do not sell to patients.

transferrin fragment Chemical Structure

Size Price Stock Qty
1mg
$60.00
In stock
5mg
$180.00
In stock
10mg
$300.00
In stock
25mg
$420.00
In stock

Tel:(909) 407-4943 Email: sales@glpbio.com

Customer Reviews

Based on customer reviews.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

View current batch:

Background

Transferrin is the principal ironbinding protein in animal serum and is analogous in its iron-binding site and properties to lactoferrin1. Human transferrin is a single-chain glycoprotein of molecular weight near 80,000. The molecule is arranged in two lobes, each bearing a single metal-binding site. Although similar in ligand structure2, 3, the sites are distinguishable in many of their properties 4, 5. Sequence homology between the lobes6 and internal homology in organization of the transferrin gene7 establish that the modern protein arose by duplication and fusion of a primitive gene specifying a single-sited transferrin precursor protein.

Each lobe of the transferrin molecule contains a recognition site for the chick receptor, and that both lobes are required for binding to receptor8. The receptor-binding activity of human transferrin is essentially confined to the C-terminal lobe and is preserved in the C-fragment even in the absence of the N-fragment.

References:
1.M. C. Custer And J. Norman Hansen, Lactoferrin and Transferrin Fragments React with Nitrite To Form an Inhibitor of Bacillus cereus Spore Outgrowth, Applied And Environmental Microbiology, Mar. 942-949, 1983
2.Anderson,? B.? F.,? Baker, H. M.,? Dodson, E. J., N o m s ,? G. E., Rumball,? S. V., Waters, J. M.,? and? Baker,? E.? N. (1987) Proc. Natl.? Acad.? Sei.? U. S. A. 84, 1769-1773
3.Bailey, S., Evans, R.? W., Garratt, R. C . ,? Gorinsky, B., Hasnain, S., Horsburgh, C., Jhoti, H., Lindley, P. F.,? Mydin, A., Sarra, R.,? and Watson, J. L. (1988) Biochemistry 27, 5804-5812
4.Aisen, P. (1989) in Iron Carriers and Iron Proteins (Loehr, T. M.,? Gray, H. B., and Lever, H. B. P., eds) pp. 353-371, VCH Publishers, Weinheim.
5.Harris, D. C., and Aisen, P. (1989) in Iron Carriers and Iron Proteins (Loehr, T. M., Gray, H. B., and Lever, A.? B. P.,? eds) pp.? 239351, VCH Publishers, Weinheim.
6.MacGillivray, R. T. A,, Mendez, E.,? Shewale, J. G., Sinha, S. K., Lineback-Zins, J., and Brew, K. (1983) J. Biol.? Chem. 258,3543-3553
7.Park, I., Schaeffer, E., Sidoli, A,, Baralle, F. E., Cohen, G. N., and Zakin, M.? M. (1985) Proc. Natl.? Acad. Sci. U. S. A. 82, 3149-3153
8.Olga Zaks, Deborah *hinder, and Philip AisenSB, Primary Receptor-Recognition Site of Human Transferrin Is in the C-terminal Lobe.? The Journal of Biological Chemistry. 269: 7110-7114,? 1994

Chemical Properties

Cas No. SDF
Synonyms H2N-Ala-Asp-Arg-Asp-Gln-Tyr-Glu-Leu-Leu-Cys-Leu-Asp-Asn-Thr-Arg-OH
Canonical SMILES NC(C)C(NC(CC(O)=O)C(NC(CCCNC(N)=N)C(NC(CC(O)=O)C(NC(CCC(N)=O)C(NC(CC1=CC=C(O)C=C1)C(NC(CCC(O)=O)C(NC(CC(C)C)C(NC(CC(C)C)C(NC(CS)C(NC(CC(C)C)C(NC(CC(O)=O)C(NC(CC(N)=O)C(NC(C(C)O)C(NC(CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Formula C75H121N23O28S M.Wt 1824.97
Solubility ≥182.4mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 0.548 mL 2.7398 mL 5.4795 mL
5 mM 0.1096 mL 0.548 mL 1.0959 mL
10 mM 0.0548 mL 0.274 mL 0.548 mL
  • Molarity Calculator

  • Dilution Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

Calculate

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for transferrin fragment

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for transferrin fragment

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.