TRAP-6 amide (trifluoroacetate salt) (Synonyms: Ser-Phe-Leu-Leu-Arg-Asn-NH2, SFLLRN-NH2, Thrombin Receptor Agonist Peptide-6 amide) |
Catalog No.GC52436 |
A peptide PAR1 agonist
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
TRAP-6 amide is a peptide agonist of proteinase-activated receptor 1 (PAR1).1 It induces platelet aggregation in vitro (EC50 = 0.15 µM). TRAP-6 amide (30 µM) induces relaxation of isolated guinea pig internal anal sphincter strips.2 It also increases cigarette smoke extract-induced IL-8 release from isolated human bronchial epithelial cells when used at a concentration of 50 µM.3
1.Elliott, J.T., Hoekstra, W.J., Derian, C.K., et al.Tritiated photoactivatable analogs of the native human thrombin receptor (PAR-1) agonist peptide, SFLLRN-NH2J. Pept. Res.57(6)494-506(2001) 2.Huang, S.-C.Proteinase-activated receptor-1 (PAR1) and PAR2 mediate relaxation of guinea pig internal anal sphincterRegul. Pept.18946-50(2014) 3.Montalbano, A.M., Chiappara, G., Albano, G.D., et al.Expressioctivation of PAR-1 in airway epithelial cells of COPD patients: Ex vivo/in vitro studyInt. J. Mol. Sci.22(19)10703(2021)
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