TRV-120027 |
| Catalog No.GC70070 |
TRV120027 is a β-arrestin-1 agonist for angiotensin II type 1 receptor (AT1R). TRV120027 induces acute catecholamine secretion through coupling with the cation channel subfamily C3 (TRPC3), promoting the formation of a large molecular complex consisting of AT1R-β-arrestin-1-TRPC3-PLCγ on the plasma membrane. TRV120027 inhibits angiotensin II-mediated vasoconstriction and increases myocardial contractility. It has potential for use in research on acute decompensated heart failure (ADHF).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1234510-46-3
Sample solution is provided at 25 µL, 10mM.
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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