UC-514321 |
| Catalog No.GC39457 |
UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 299420-83-0
Sample solution is provided at 25 µL, 10mM.
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UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity[1].
[1]. Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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