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UCB9608

Catalog No.GC18164

PI4KIIIβ inhibitor

Products are for research use only. Not for human use. We do not sell to patients.

UCB9608 Chemical Structure

Cas No.: 1616413-96-7

Size Price Stock Qty
5mg
$155.00
In stock
25mg
$464.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

UCB9608 (UCB-9608) is a potent, selective, orally bioavailable PI4KIIIβ inhibitor with IC50 of 11 nM; also shows an IC50 of 37 nM in the human mixed lymphocyte reaction (HuMLR) assay, only inhibits the PI4KIIIβ and PI3KC2 α, β and γ lipid kinases in apnel of 250 kinases tested at 10 uM; UCB9608 is vastly more soluble, selective compound with improved metabolic stability and excellent pharmacokinetic profile, significantly prolongs allogeneic organ engraftment in vivo.

References:
1. Reuberson J, et al. J Med Chem. 2018 Jun 28. doi: 10.1021/acs.jmedchem.8b00521.

Chemical Properties

Cas No. 1616413-96-7 SDF
Chemical Name (S)-4-(6-amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methylphenyl)-3-methylpiperazine-1-carboxamide
Canonical SMILES CN1N=CC2=C(N3[C@@H](C)CN(C(NC4=CC=C(OC)C=C4C)=O)CC3)N=C(N)N=C21
Formula C20H26N8O2 M.Wt 410.482
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.4362 mL 12.1808 mL 24.3616 mL
5 mM 0.4872 mL 2.4362 mL 4.8723 mL
10 mM 0.2436 mL 1.2181 mL 2.4362 mL
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for UCB9608

Average Rating: 5 ★★★★★ (Based on Reviews and 24 reference(s) in Google Scholar.)

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