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UCB9608 Catalog No.GC18164

PI4KIIIβ inhibitor

Size Price Stock Qty
5mg
$155.00
In stock
25mg
$464.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & SDS

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Chemical Properties

Cas No. 1616413-96-7 SDF Download SDF
Synonyms N/A
Chemical Name (S)-4-(6-amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methylphenyl)-3-methylpiperazine-1-carboxamide
Canonical SMILES CN1N=CC2=C(N3[C@@H](C)CN(C(NC4=CC=C(OC)C=C4C)=O)CC3)N=C(N)N=C21
Formula C20H26N8O2 M.Wt 410.482
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

UCB9608 (UCB-9608) is a potent, selective, orally bioavailable PI4KIIIβ inhibitor with IC50 of 11 nM; also shows an IC50 of 37 nM in the human mixed lymphocyte reaction (HuMLR) assay, only inhibits the PI4KIIIβ and PI3KC2 α, β and γ lipid kinases in apnel of 250 kinases tested at 10 uM; UCB9608 is vastly more soluble, selective compound with improved metabolic stability and excellent pharmacokinetic profile, significantly prolongs allogeneic organ engraftment in vivo.

References:
1. Reuberson J, et al. J Med Chem. 2018 Jun 28. doi: 10.1021/acs.jmedchem.8b00521.