uPSEM 817 tartrate |
| Catalog No.GC50587 |
Highly potent and selective PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2341833-14-3
Sample solution is provided at 25 µL, 10mM.
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Selective ultrapotent PSEM (uPSEM) agonist for α7L131G,Q139L,Y217F-GlyR (PSAM4-GlyR) and PSAM4-5-HT3 chimeric ion channel agonist (EC50 values are 0.3 and 0.5 nM, respectively). Suppresses firing of layer 2/3 cortical neurons expressing PSAM4-GlyR in brain slices. Increases contralateral rotation in mice expressing PSAM4-GlyR unilaterally in the substantia nigra reticulata (LED 0.1 mg/kg).
Magnus et al (2019) Ultrapotent chemogenetics for research and potential clinical applications. Science 364 PMID:30872534
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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