Vanoxonin (Synonyms: Antibiotic MG 245CF2A) |
| Catalog No.GC48533 |
A bacterial metabolite
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 86933-99-5
Sample solution is provided at 25 µL, 10mM.
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Vanoxonin is a bacterial metabolite that has been found in S. hirsuta.1 It forms a complex with vanadium, and the complex inhibits thymidylate synthetase with an IC50 value of 0.7 µg/ml. The vanoxonin-vanadium complex is cytotoxic to L1210 leukemia cells (MIC = 25 µg/ml) and increases survival in Ehrlich murine spontaneous adenocarcinoma and L1210 mouse tumor models.
1.Kanai, F., Sawa, T., Hamada, M., et al.Vanoxonin, a new inhibitor of thymidylate synthetaseJ. Antibiot. (Tokyo)36(6)656-660(1983)
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