Zofenopril calcium (Synonyms: SQ 26,911) |
| Catalog No.GC11513 |
angiotensin converting enzyme (ACE) inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 81938-43-4
Sample solution is provided at 25 µL, 10mM.
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Zofenopril Calcium (SQ26991) is an antioxidant that acts as an angiotensin-converting enzyme inhibitor.Target: ACEZofenopril Calcium is a pro-drug designed to undergo metabolic hydrolysis yielding the active free sulfhydryl compound zofenoprilat, which is an angiotensin converting enzyme (ACE) inhibitor [1]. Zofenopril Calcium promotes the regeneration of peripheral nerve injuries in rat models [2]. Zofenopril Calcium increases SR calcium cycling and stimulates active calcium uptake into the SR [3].
References:
[1]. Dal Bo, L., P. Mazzucchelli, and A. Marzo, Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry. J Chromatogr B Biomed Sci Appl, 2000. 749(2): p. 287-94.
[2]. Kalender, A.M., et al., Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model. J Brachial Plex Peripher Nerve Inj, 2009. 4: p. 6.
[3]. Frascarelli, S., et al., Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling. J Cardiovasc Pharmacol, 2009. 54(5): p. 456-63.
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