Reactive Oxygen Species
Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.
ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Targets for Reactive Oxygen Species
Products for Reactive Oxygen Species
- Cat.No. Product Name Information
-
GC45226
β-BHC
β-HCH, β-Hexachlorocyclohexane, β-Lindane
β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane. -
GC41623
β-Elemonic Acid
Elemadienonic Acid, 3-Oxotirucallenoic Acid, 3-oxo Tirucallic Acid
β-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity. -
GC41502
β-Myrcene
NSC 406264
β-Myrcene is a terpene that has been found in Cannabis and has antioxidative properties. -
GC41262
(±)-α-CMBHC
Vitamin E is a well known antioxidant that exists in eight natural forms: four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ).
-
GC41617
(±)-α-Tocopherol
all-rac-α-Tocopherol, DL-α-Tocopherol
(±)-α-Tocopherol is a synthetic vitamin E, with antioxidation effect. -
GC67191
(±)-α-Tocopherol nicotinate
(±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases.
-
GC39271
(±)-Naringenin
SDihydrogenistein, NSC 11855, NSC 34875, Salipurol
A citrusderived flavonoid -
GC40355
(±)13-HpODE
13-Hydroperoxylinoleic acid; Linoleic acid 13-hydroperoxide
(±)13-HpODE is a racemic mixture of hydroperoxides derived non-enzymatically from linoleic acid through the action of reactive oxygen species.
-
GC40809
(+)-β-Citronellol
(R)-Citronellol, (+)-Citronellol, (+)-(R)-Citronellol, (R)-(+)-β-Citronellol
(+)-β-Citronellol (D-Citronellol) is an alcoholic monoterpene found in geranium essential oil. -
GC63969
(+)-Schisandrin B
(+)-Schisandrin B is an enantiomer of Schisandrin B.
-
GC14049
(-)-Epigallocatechin gallate (EGCG)
EGCG
(-)-Epigallocatechin Gallate sulfate (EGCG) is a major polyphenol in green tea that inhibits cell proliferation and induces apoptosis. -
GC45248
(-)-FINO2
(-)-FINO2 is a ferroptosis-inducing peroxide compound that indirectly inhibits glutathione peroxidase 4 (GPX4) and oxidizes iron.
-
GC38316
(-)-Limonene
(±)-Dipentene, DL-Limonene, NSC 844, NSC 21446
(-)-Limonene ((S)-(-)-Limonene) is a monoterpene found in many pine-needle oils and in turpentine. -
GC90533
(-)-Pinoresinol
A lignan with diverse biological activities
-
GC41700
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine
CSTMP
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. -
GC61668
(E)-3,4-Dimethoxycinnamic acid
(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid.
-
GC39747
(E/Z)-GSK5182
(E/Z)-GSK5182 is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers.
-
GC41721
(R)-α-Lipoic Acid
(R)-(+)-Lipoic Acid
(R)-α-Lipoic acid is the naturally occurring enantiomer of lipoic acid, a cyclic disulfide antioxidant. -
GC41837
1,3,7-Trimethyluric Acid
8-oxo Caffeine, NSC 11259
1,3,7-Trimethyluric acid is a methyl derivative of uric acid and a product of C-8 oxidation of caffeine by cytochrome P450 enzymes.
-
GC46387
1,3,7-Trimethyluric Acid-d9
TMU-d9, 8-oxo Caffeine-d9
An internal standard for the quantification of 1,3,7-trimethyluric acid -
GC35037
1,3-Dicaffeoylquinic acid
1,5-DCQA, 1,3-Dicaffeoylquinic Acid
1,3-Dicaffeoylquinic acid is a caffeoylquinic acid derivative, and activates PI3K/Akt. -
GC46481
1-Hydroxyphenazine
Hemipyocyanine, NSC 88882
A P. aeruginosa virulence factor -
GC18235
1-O-Hexadecyl-sn-glycerol
α-Chimyl Alcohol, (S)-(+)-Chimyl Alcohol
1-O-Hexadecyl-sn-glycerol is a bioactive alkyl glyceryl ether.
-
GC40146
1-Oleoyl-2-Palmitoyl-rac-glycerol
18:1/16:0-DG, DG(18:1/16:0/0:0), 1,2-OP, 1-Olein-2-Palmitin
1-Oleoyl-2-palmitoyl-rac-glycerol (1,2-OP) is a diacylglycerol containing oleic acid at the sn-1 position and palmitic acid at the sn-2 position. -
GC41866
10-methyl-9-(phenoxycarbonyl) Acridinium (trifluoromethylsulfonate)
10-methyl-9-(phenoxycarbonyl) Acridinium is an acridinium ester that produces fluorescent 10-methyl-9-acridone upon oxidation with hydrogen peroxide, persulfates, and other oxidants in alkaline conditions.
-
GC41868
10-Nitrooleate
10Nitrooleic Acid, 10nitro9transOctadecenoic Acid
10-Nitrooleate (CXA-10), a nitro fatty acid, has potential effects in disease states in which oxidative stress, inflammation, fibrosis, and/or direct tissue toxicity play significant roles. -
GC67628
2',7'-Dichlorofluorescein
2',7'-Dichlorofluorescein acts as a fluorescent probe (Ex=496 nm and Em=525 nm) for reactive oxygen species (ROS) measurement.
-
GC42079
2',7'-Dichlorofluorescein diacetate
DCFDA, MFCD 37501
2',7'-Dichlorofluorescein diacetate is as a cell-permeable fluorogenic probe to quantify reactive oxygen species (ROS) and nitric oxide (NO).
-
GC46057
2,5-Dihydroxycinnamic Acid phenethyl ester
An inhibitor of 5-LO
-
GC72574
2-Oxopropanoate-13C5 sodium
2-Oxopropanoate-13C5 (sodium) is the 13C labeled Sodium 2-oxopropanoate.
-
GC35095
2-Phospho-L-ascorbic acid trisodium salt
2-Phospho-L-ascorbic acid trisodium salt (2-Phospho-L-ascorbic acid trisodium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression.
-
GC49005
2S-Eriodictyol
(+)-Eriodictyol
A flavanone with antioxidant activity -
GN10006
3,4-Dihydroxybenzaldehyde
NSC 22961, Protocatechualdehyde, Protocatechuic aldehyde
-
GC33992
3,4-Dimethoxycinnamic acid (O-Methylferulic acid)
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk.
-
GC61673
3,5-Di-tert-butylphenol
3,5-Di-tert-butylphenol is an volatile organic compound with anti-biofilm and antifungal activities.
-
GC52324
3-(3-Hydroxyphenyl)propionic Acid sulfate
3-HPPA sulfate
A metabolite of certain phenols and glycosides -
GC14282
3-acetyl-11-keto-β-Boswellic Acid
3-O-acetyl-11-keto-β-Boswellic acid,AKBA
3-acetyl-11-keto-β-Boswellic Acid (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator. -
GC49849
3-Aminosalicylic Acid
3-ASA, NSC 285111
A salicylic acid derivative -
GC42251
3-Bromotyrosine (trifluoroacetate salt)
3-bromo-Tyr
3-Bromotyrosine is a product of protein oxidation found after activation of eosinophils during an allergic response. -
GC62794
3-Demethylcolchicine
(-)-3-Demethylcolchicine
3-Demethylcolchicine, a colchicine metabolite, possesses a hydroxy-group on its carbon ring that could participate in radical scavenging and markedly inhibits the carrageenin edema. -
GC49364
3-Hydroxycoumarin
3-Coumarinol, NSC 74691
A coumarin with diverse biological activities -
GC45337
3-Hydroxyterphenyllin
NSC 299113
3-Hydroxyterphenyllin is a metabolite of Aspergillus candidus.3-Hydroxyterphenyllin suppresses proliferation and causes cytotoxicity against A2780/CP70 and OVCAR-3 cells. 3-Hydroxyterphenyllin induces S phase arrest and apoptosis. 3-Hydroxyterphenyllin has the potential for the research of ovarian cancer. -
GC31290
3-Indolepropionic acid
3-Indolepropionic Acid, NSC 3252, NSC 47831
A bacterial metabolite with antioxidant and neuroprotective activities -
GC74668
3-Methoxy-9H-Carbazole
3-Methoxy-9H-Carbazole induces caspase-3 activities and the cellular generation of eactive oxygen species.
-
GC42338
4-Aminobenzoic Acid hydrazide
4ABAH, Myeloperoxidase Inhibitor 1, NSC 640
4-Aminobenzoic Acid hydrazide is an irreversible MPO myeloperoxidase inhibitor with an IC50 of 0.3 μM. -
GC42351
4-carboxy TEMPO
4-Carboxyl-2,2,6,6-tetramethylpiperidin-1-oxyl
4-carboxy TEMPO is a nitroxide and spin label. -
GC42401
4-hydroperoxy Cyclophosphamide
4-OOH-CY
4-hydroperoxy Cyclophosphamide, the active metabolite of cyclophosphamide, can cross-link DNA and induce T cell apoptosis independently of caspase receptor activation. It also activates the mitochondrial death pathway through the production of reactive oxygen species (ROS). -
GC18858
4-hydroxy Alternariol
4-hydroxy AOH, 4-OH AOH
4-hydroxy Alternariol is a metabolite of the mycotoxin alternariol formed through cytochrome P450 (CYP450) metabolism. -
GC72066
4-Methyl-6-phenyl-2H-pyranone
4-Methyl-6-phenyl-2H-pyranone can be used for the synthesis of N-hydroxypyridone derivatives, which can protect astrocytes against hydrogen peroxide-induced toxicity via improved mitochondrial functionality.
-
GC40477
4-Thiouracil
2-hydroxy-4-Mercaptopyrimidine, NSC 43288, 4-Thiopyrimidin-2-one, 4-TU
4-Thiouracil is a site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts. -
GC49339
5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate
CDFDA
An oxidant-sensitive fluorescent probe -
GC20095
5,7-Dihydroxy-4-methylcoumarin
NSC 5302
5,7-Dihydroxy-4-methylcoumarin is a coumarin derivative from Mexican tarragon. 5,7-Dihydroxy-4-methylcoumarin possesses antifungal and antibacterial activities.
-
GC52227
5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone
(±)-δ-(3,4-Dihydroxyphenyl)-γ-Valerolactone, 5-(3',4'-Dihydroxyphenyl)-γ-VL
An active metabolite of various polyphenols -
GC90889
5-(3'-Hydroxyphenyl)-γ-Valerolactone
A metabolite of various polyphenols
-
GC45357
5-Chlorouracil
-
GC49233
5-Feruloylquinic Acid
5-FQA
A chlorogenic acid with antioxidant activity -
GC39760
5-Galloylquinic acid
5-Galloylquinic acid, an main scavenger of the reactive oxygen species (ROS) in green tea.
-
GC46033
5-Heneicosylresorcinol
An alkylresorcinol
-
GC61638
5-Hydroxyoxindole
5-Hydroxyoxindole is a structural analog of uric acid.
-
GC46079
5-Tricosylresorcinol
5-Tricosylresorcinolthe is the first cyst lipid.
-
GC49864
6-Methylpterin
6-MPT
A derivative of folic acid -
GC18776
6α-hydroxy Cholesterol
6α-OHC
6α-hydroxy Cholesterol is an oxysterol that increases superoxide anion production in SK-N-BE cells when used at concentrations of 50 and 100 μM.
-
GC46080
7,3',4'-Trihydroxyflavone
3’,4’,7-Trihydroxyflavone, 5-Deoxyluteolin
7,3',4'-Trihydroxyflavone is a flavonoid aglycon compound isolated from broad bean pods. -
GC63640
7-Hydroxyflavone
NSC 94258, 7-hydroxy-2-Phenylchromone
7-Hydroxyflavone is a flavonoid isolated from M. -
GC42627
8-Hydroxyguanine (hydrochloride)
NSC 22720, 8Oxoguanine
8-Hydroxyguanine is produced by oxidative degradation of DNA by hydroxyl radical. -
GC92043
9(10)-Nitrooleate
9(10)-Nitrooleic Acid; OA-NO2; 9(10)-nitro-9-trans-Octadecenoic Acid
9(10)-Nitrooleate is a mixture of the nitroalkene endogenous lipid signaling molecules 9-nitrooleate. -
GC42642
9,10-Anthracenediyl-bis(methylene)dimalonic Acid
ABMDMA
9,10-Anthracenediyl-bis(methylene)dimalonic acid (ABMDMA) is a reagent used to detect singlet oxygen generation.
-
GC42649
9-Nitrooleate
9Nitrooleic Acid, 9nitro9transOctadecenoic Acid
Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate, cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. -
GC19496
AAPH
AAPH is a water-soluble azo compound
-
GC63975
Acanthoside B
Acanthoside B is a potential bioactive lignan with anti-inflammatory and anti-amnesic activities.
-
GC11786
Acetylcysteine
N-acetylcysteine; N-acetyl-L-cysteine; NAC; Acetadote
Acetylcysteine is the N-acetyl derivative of CYSTEINE. -
GN10298
Alibiflorin
-
GC45379
Alloxan (hydrate)
-
GC11443
Allylthiourea
Selective inhibitor of ammonia oxidation
-
GC35306
alpha-Mangostin
alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
-
GN10484
Amentoflavone
Didemethyl Ginkgetin, NSC 295677
-
GC49336
AMK (hydrochloride)
N-γ-acetyl-5-Methoxykynurenamine, N1-acetyl-5-Methoxykynuramine
An active metabolite of melatonin -
GC49259
Antagonist G (trifluoroacetate salt)
Arg-D-Trp-NmePhe-D-Trp-Leu-Met-NH2, Arg6,D-Trp7,9,NmePhe8-substance P (6-11)
A neuropeptide antagonist -
GC70979
Anti-inflammatory agent 38
Anti-inflammatory agent 38 (compound 23d) is a potent Nrf2/HO-1 pathway inhibitor, with an IC50 value of 0.38 μM for NO.
-
GC42819
Antimycin A3
Antimycin A3 is a component of the antimycin A antibiotic complex that is more polar than antimycin A1 and antimycin A2 but not antimycin A4.
-
GC42825
APF
APF is a novel ROS indicator that selectively and dose-dependently fluoresces upon binding to certain reactive oxygen species in solution and in cells with a maximum excitation/emission wavelength of 490/515 nm.
-
GN10509
Apigenin-7-O-β-D-glucopyranoside
7-O-β-D-Glucopyranosylapigenin, Apigenin-7-O-β-D-glucoside, Apigetrin, Cosmosiin, NSC 407303
-
GC52332
Arimoclomol
BRX-220
A co-inducer of heat shock proteins -
GC46005
Arjunolic Acid
A triterpene with diverse biological activities
-
GC70612
Arochlor 1254
Arochlor 1254 is a polychlorinated biphenyl (PCB) mixture with biphenyl and 54% chlorine.
-
GC12070
Ascorbic acid (Standard)
Ascorbate, NSC 33832, NSC 218455, Vitamin C
An electron donor -
GN10534
Asiaticoside
Ba 2742, NSC 36002, NSC 166062
-
GC31350
Astaxanthin
Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant.
-
GC72858
Avenanthramide A
Avenanthramide A is a ptoalexin, which can be found in oats (Avena sativa L.
-
GC48771
Avobenzone-13C-d3
BMDBM-13C-d3, Butyl Methoxydibenzoylmethane-13C-d3
-
GC46904
Azoxystrobin
ICI-A 5504
A broad-spectrum fungicide -
GC60616
AZT triphosphate
3'-Azido-3'-deoxythymidine-5'-triphosphate
AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) is a active triphosphate metabolite of Zidovudine (AZT). -
GC60617
AZT triphosphate TEA
3'-Azido-3'-deoxythymidine-5'-triphosphate TEA
AZT triphosphate TEA (3'-Azido-3'-deoxythymidine-5'-triphosphate TEA) is a active triphosphate metabolite of Zidovudine (AZT). -
GC45820
Balsalazide-d4
A neuropeptide with diverse biological activities
-
GC17574
BAPTA
calcium chelator
-
GC15949
Benfotiamine
Benzoylthiamine monophosphate
A lipid-soluble form of vitamin B1 -
GN10221
Berberine
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase.
-
GC35497
Berberine chloride hydrate
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.
-
GN10208
Berberine hydrochloride
BBR, Umbellatine, NSC 163088, NSC 646666
Berberine hydrochloride is a bioactive alkaloid of the isoquinoline class derived from the medicinal plant Coptis chinensis of the Ranunculaceae family, possessing a wide range of pharmacological functions with applications in cancer, inflammation, diabetes, depression, hypertension, and various infections. -
GN10523
Berberine Sulfate