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Home >> Signaling Pathways >> Tyrosine Kinase >> LRRK2

LRRK2

LRRK2 (Leucine-rich repeat kinase 2) is an enzyme that interacts with parkin and is associated with Parkinson's disease and also Crohn's disease.

Products for  LRRK2

  1. Cat.No. Product Name Information
  2. GC16731 CZC 54252 hydrochloride CZC 54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. CZC 54252 hydrochloride Chemical Structure
  3. GC16038 CZC-25146 LRRK2 inhibitor CZC-25146 Chemical Structure
  4. GC35792 CZC-25146 hydrochloride CZC-25146 hydrochloride is a potent LRRK2 inhibitor with IC50 values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively. CZC-25146 hydrochloride Chemical Structure
  5. GC64730 EB-42486 EB-42486 is a novel, potent, and highly selective G2019S-LRRK2 inhibitor (IC50 < 0.2 nM). EB-42486 Chemical Structure
  6. GC12121 GNE-7915 Potent and selective LRRK2 inhibitor GNE-7915 Chemical Structure
  7. GC36171 GNE-7915 tosylate GNE-7915 tosylate is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM. GNE-7915 tosylate Chemical Structure
  8. GC13868 GNE-9605 LRRK2 inhibitor, brain-penetrant, potent and selective GNE-9605 Chemical Structure
  9. GC15196 GNE0877 Potent and selective LRRK2 inhibitor GNE0877 Chemical Structure
  10. GC18049 GSK2578215A LRRK2 inhibitor GSK2578215A Chemical Structure
  11. GC13098 HG-10-102-01 LRRK2 inhibitor HG-10-102-01 Chemical Structure
  12. GC12370 IKK-16 (hydrochloride) IκB kinases (IKKs) inhibitor IKK-16 (hydrochloride) Chemical Structure
  13. GC12180 IKK-16 (IKK Inhibitor VII) IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. IKK-16 (IKK Inhibitor VII) Chemical Structure
  14. GC19205 JH-II-127 JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T. JH-II-127 Chemical Structure
  15. GC65390 LRRK2 inhibitor 1 LRRK2 inhibitor 1 is a potent, selective and oral LRRK2 inhibitor with an pIC50 of 6.8. LRRK2 inhibitor 1 Chemical Structure
  16. GC10809 LRRK2-IN-1 A selective LRRK2 inhibitor LRRK2-IN-1 Chemical Structure
  17. GC30769 MLi-2 An LRRK2 inhibitor MLi-2 Chemical Structure
  18. GC13850 PF-06447475 LRRK2 inhibitor PF-06447475 Chemical Structure
  19. GC64566 PF-06454589 PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06454589 Chemical Structure
  20. GC64506 PF-06456384 trihydrochloride PF-06447475 trihydrochloride is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06456384 trihydrochloride Chemical Structure
  21. GC36888 PFE-360 PFE-360 (PF-06685360) is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo. PFE-360 Chemical Structure

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