1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) (Synonyms: DODMA; MBN 305A) |
Catalog No.GC41817
One-Click Copy Product Info
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1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) is an environmentally ionized cationic lipid, exhibiting positive charge at low pH with moderate pKa value.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 104162-47-2
Sample solution is provided at 25 µL, 10mM.
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1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) is an environmentally ionized cationic lipid, exhibiting positive charge at low pH with moderate pKa value [1]. 1,2-Dioleyloxy-3-dimethylamino-propane is effective in encapsulating nucleic acids during synthesis by temporarily reducing pH, which can be used for the delivery of RNA[2]. 1,2-Dioleyloxy-3-dimethylamino-propane can be modified with 4-(bromomethyl) phenylboronic acid (PBA) or 3-fluoro-4-(bromomethyl) phenylboronic acid (FPBA) to obtain quaternary ammonium compounds, which can be used to construct glucose-responsive insulin delivery carriers[3]. 1,2-Dioleyloxy-3-dimethylamino-propane can be mixed with cholesterol in a 2:1 ratio to prepare the nanovesicle formulation, which is used to protect dsRNA from being degraded by nucleases and is easily absorbed by Botrytis cinerea [4].
References:
[1] Chen Z, Zhang A, Yang Z, et al. Application of DODMA and derivatives in cationic nanocarriers for gene delivery[J]. Current Organic Chemistry, 2016, 20(17): 1813-1819.
[2] Sun X, Setrerrahmane S, Li C, et al. Nucleic acid drugs: recent progress and future perspectives[J]. Signal transduction and targeted therapy, 2024, 9(1): 316.
[3] Liu Y, Wang Y, Yao Y, et al. Glucose‐responsive charge‐switchable lipid nanoparticles for insulin delivery[J]. Angewandte Chemie International Edition, 2023, 62(20): e202303097.
[4] Qiao L, Niño‐Sánchez J, Hamby R, et al. Artificial nanovesicles for dsRNA delivery in spray‐induced gene silencing for crop protection[J]. Plant Biotechnology Journal, 2023, 21(4): 854-865.
| Cas No. | 104162-47-2 | SDF | |
| Synonyms | DODMA; MBN 305A | ||
| Chemical Name | N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine | ||
| Canonical SMILES | CN(C)CC(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC | ||
| Formula | C41H81NO2 | M.Wt | 620.1 |
| Solubility | 12mg/mL in DMF | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.6126 mL | 8.0632 mL | 16.1264 mL |
| 5 mM | 322.5 μL | 1.6126 mL | 3.2253 mL |
| 10 mM | 161.3 μL | 806.3 μL | 1.6126 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solution in ethanol
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)