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(±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic Acid (Synonyms: αHYA, (±)-10-hydroxy-12(Z),15(Z)-ODE)

Catalog No.GC52010

An oxylipin gut microbiota metabolite

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(±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic Acid Chemical Structure

Cas No.: 34932-14-4

Size Price Stock Qty
25 µg
$82.00
In stock
50 µg
$132.00
In stock
100 µg
$181.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic acid is an oxylipin. It is produced from α-linolenic acid by the gut bacteria L. plantarum.1 (±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic acid prevents increases in mRNA expression of the gene encoding SREBP-1c by the liver X receptor (LXR) agonist T0901317 in HepG2 cells. It reduces LPS-induced increases in nitric oxide (NO) production in RAW 264.7 macrophages when used at a concentration of 10 µM.2

1.Nanthirudjanar, T., Furumoto, H., Zheng, J., et al.Gut microbial fatty acid metabolites reduce triacylglycerol levels in hepatocytesLipids50(11)1093-1102(2015) 2.Yang, H.-E., Li, Y., Nishimura, A., et al.Synthesized enone fatty acids resembling metabolites from gut microbiota suppress macrophage-mediated inflammation in adipocytesMol. Nutr. Food Res.61(10)(2017)

Chemical Properties

Cas No. 34932-14-4 SDF Download SDF
Synonyms αHYA, (±)-10-hydroxy-12(Z),15(Z)-ODE
Canonical SMILES CC/C=C\C/C=C\CC(O)CCCCCCCCC(O)=O
Formula C18H32O3 M.Wt 296.5
Solubility Ethanol: 1 mg/ml Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.3727 mL 16.8634 mL 33.7268 mL
5 mM 0.6745 mL 3.3727 mL 6.7454 mL
10 mM 0.3373 mL 1.6863 mL 3.3727 mL
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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