Home>>2-chloro-N6-Cyclopentyladenosine (hydrate)

2-chloro-N6-Cyclopentyladenosine (hydrate) (Synonyms: CCPA)

Catalog No.GC45773

A neuropeptide with diverse biological activities

Products are for research use only. Not for human use. We do not sell to patients.

2-chloro-N6-Cyclopentyladenosine (hydrate) Chemical Structure

Cas No.: N/A

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5mg
$128.00
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10mg
$205.00
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25mg
$482.00
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50mg
$899.00
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Sample solution is provided at 25 µL, 10mM.

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Background

2-chloro-N6-Cyclopentyladenosine is an adenosine receptor agonist.1 It binds selectively to adenosine A1 receptors over A2A and A3 receptors with Ki values of 0.83, 2,300 and 42 nM, respectively, for the human recombinant receptors expressed in CHO cells. 2-chloro-N6-Cyclopentyladenosine decreases heart rate in isolated rat atria (EC50 = 8.2 nM) but does not affect vasodilation in bovine coronary arteries.2 It inhibits convulsions induced by isoniazid and pentylenetetrazole in mice when administered at a dose of 8.3 μmol/kg.3

|1. Cristalli, G., Camaioni, E., Costanzi, S., et al. Characterization of potent ligands at human recombinant adenosine receptors. Drug Develop. Res. 45(3‐4), 176-181 (1998).|2. Monopoli, A., Conti, A., Dionisotti, S., et al. Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine. Arzneimittelforschung 44(12), 1305-1312 (1994).|3. Concas, A., Santoro, G., Mascia, M.P., et al. Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain. J. Pharmacol. Exp. Ther. 267(2), 844-851 (1993).

Chemical Properties

Cas No. N/A SDF
Synonyms CCPA
Canonical SMILES OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C(NC4CCCC4)N=C(Cl)N=C32)O1
Formula C15H20ClN5O4.0.5H2O M.Wt 378.8
Solubility DMSO: soluble,Water: soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Average Rating: 5 ★★★★★ (Based on Reviews and 18 reference(s) in Google Scholar.)

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