6-Deoxypenciclovir (Synonyms: BRL 42359) |
| Catalog No.GC49749 |
An inactive metabolite of famciclovir
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 104227-86-3
Sample solution is provided at 25 µL, 10mM.
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6-Deoxypenciclovir is an inactive metabolite of the antiviral prodrug famciclovir .1,2 It is formed from famciclovir via hydrolysis and is further metabolized via oxidation by aldehyde oxidase to the active metabolite penciclovir . 6-Deoxypenciclovir has been used in the synthesis of prodrug forms of penciclovir.3
1.Rashidi, M.R., Smith, J.A., Clarke, S.E., et al.In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liverDrug Metab. Dispos.25(7)805-813(1997) 2.Groth, A.D., Contreras, M.T., Kado-Fong, H.K., et al.In vitro cytotoxicity and antiviral efficacy against feline herpesvirus type 1 of famciclovir and its metabolitesVet. Ophthalmol.17(4)268-274(2014) 3.Kim, D.K., Lee, N., Ryu, D.H., et al.Synthesis and evaluation of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines and 2-amino-9-(3-alkoxycarbonyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines as potential prodrugs of penciclovirBioorg. Med. Chem.7(8)1715-1725(1999)
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