7-Ethoxy-4-(trifluoromethyl)coumarin (Synonyms: EFC) |
| Catalog No.GC49320 |
A fluorogenic substrate for CYPs
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 115453-82-2
Sample solution is provided at 25 µL, 10mM.
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7-Ethoxy-5-(trifluoromethyl)coumarin is a fluorogenic substrate for cytochrome P450s (CYPs).1 Upon O-deethylation by CYPs, 7-hydroxy-4-(trifluoromethyl)coumarin (HFC) is released and its fluorescence can be used to quantify CYP activity. HFC displays excitation/emission maxima of 410/510 nm, respectively.
1.Buters, J.T.M., Schiller, C.D., and Chou, R.C.A highly sensitive tool for the assay of cytochrome P450 enzyme activity in rat, dog and man. Direct fluorescence monitoring of the deethylation of 7-ethoxy-4-trifluoromethylcoumarinBiochem. Pharmacol.46(9)1577-1584(1993)
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