8-hydroxy Loxapine (Synonyms: 8-OH Loxapine) |
| Catalog No.GC18654 |
8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 61443-77-4
Sample solution is provided at 25 µL, 10mM.
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8-hydroxy Loxapine (8-OH loxapine) is a metabolite formed when loxapine , an atypical antipsychotic, is metabolized by the cytochrome P450 isoform CYP1A2. Loxapine displays high affinity for histamine, serotonin (5-HT), dopamine, and α1-adrenergic receptors (Ki values = 7, 7.7, 9.5, 12, and 31 nM for H1, 5-HT2A, 5-HT2C, D2, and α1A-adrenergic receptors, respectively). It reduces agitation associated with schizophrenia or bipolar disorder. 8-OH Loxapine is considered inactive as it has relatively low affinity to dopamine and 5-HT receptors compared to the parent compound, however, 8-OH loxapine inhibits [14C]5-HT uptake in vitro (IC50 = 2 μM in human platelets).
Review for 8-hydroxy Loxapine
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
Review for 8-hydroxy Loxapine
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