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Betamethasone Catalog No.GC10936

Glucocorticoid receptor agonist

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & SDS

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Cell experiment [1]:

Cell lines

Human astrocytoma

Preparation method

The solubility of this compound in DMSO is >19.6 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

10 μg/ml


Bexamethasone (1.3-50 μg/ml) decreased cloning efficiency and colony size in cultured human astrocytoma. In MRC5 human diploid fibroblasts, betamethasone (8 μg/ml) increased cloning efficiency by two-fold. Betamethasone (2-16 μg/ml) did not affect colony size.

Animal experiment [2,3]:

Animal models

Pregnant rabbits, Pregnant ewes

Dosage form

0.5 mg/kg


Pregnant rabbits were injected with either 0.8 mg of betamethasone on days 24 and 25 of gestation and delivered by cesarean section on day 26. Bexamethasone significantly reduced the weight of fetuses and fetal brain, lungs, liver, and placenta. In pregnant ewes, BET (0.5 mg/kg) decreased fetal (121–146 dG) and placental (121 dG) weights. Maternal plasma oPL levels in controls increased across gestation; fetal plasma oPL levels decreased. BNCs were reduced by 24% to 47% after BET. Placental oPL protein levels, maternal and fetal plasma oPL levels were also reduced after BET injections, but recovered to values that were not different to controls near term. BET (0.5 mg/kg) disrupted the normal distribution of BNCs within the placentome.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.


[1]. Guner M, Freshney R I, Morgan D, et al. Effects of dexamethasone and betamethasone on in vitro cultures from human astrocytoma[J]. British journal of cancer, 1977, 35(4): 439.

[2]. Barrada M I, Blomquist C H, Kotts C. The effects of betamethasone on fetal development in the rabbit[J]. American journal of obstetrics and gynecology, 1980, 136(2): 234-238.

[3]. Braun T, Li S, Moss T J M, et al. Maternal betamethasone administration reduces binucleate cell number and placental lactogen in sheep[J]. Journal of Endocrinology, 2007, 194(2): 337-347.

Chemical Properties

Cas No. 378-44-9 SDF
Chemical Name (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Canonical SMILES CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
Formula C22H29FO5 M.Wt 392.46
Solubility ≥19.6mg/mL in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Betamethasone is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.Target: Glucocorticoid ReceptorBetamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. The median (range) IC50 value for betamethasone butyrate propionate evaluated in the streptococcal pyrogenic enterotoxin A-stimulated peripheral-blood mononuclear cells was 291.6 (0.001-1171.5) ng/ml, which was significantly higher than the value 0.072 (0.01-222.5) ng/ml found in concanavalin A-stimulated peripheral-blood mononuclear cells (P=0.0245) [1]. Children exposed prenatally to betamethasone (n = 121) did not differ in systolic or diastolic blood pressure from children exposed to placebo (n = 102) (mean difference: systolic: -1.6 mm Hg; 95% confidence interval: -4.1 to 0.8 mm Hg; diastolic: -0.3 mm Hg; 95% confidence interval: -2.5 to 1.8 mm Hg) [2]. Intra-articular corticosteroid injection of 6 mg of betamethasone acetate/betamethasone sodium phosphate at the knee joint was not significantly associated with SAI at the time points tested [3].Clinical indications: Dermatitis; Discoid lupus erythematosus; Eczema; Lichen; Prurigo; PsoriasisToxicity: Symptoms of overdose include burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria.

[1]. Arai, K., et al., Comparative study of the effects of betamethasone butyrate propionate, vitamin D3 derivatives, and cyclosporine on human lymphocyte-proliferation stimulated with a hemolytic streptococci-derived superantigen. Eur J Pharmacol, 2007. 571(2-3): p. 222-30.
[2]. Dalziel, S.R., et al., Blood pressure at 6 years of age after prenatal exposure to betamethasone: follow-up results of a randomized, controlled trial. Pediatrics, 2004. 114(3): p. e373-7.
[3]. Habib, G., et al., The effect of intra-articular injection of betamethasone acetate/betamethasone sodium phosphate at the knee joint on the hypothalamic-pituitary-adrenal axis: a case-controlled study. J Investig Med, 2013. 61(7): p. 1104-7.