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Brain natriuretic peptide (1-32) (human)

Catalog No.GC17895

Brain natriuretic peptide (1-32) (human) (Brain Natriuretic Peptide-32 human) is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively.

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Brain natriuretic peptide (1-32) (human) Chemical Structure

Cas No.: 124584-08-3

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1mg
$260.00
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Sample solution is provided at 25 µL, 10mM.

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Background

Brain natriuretic peptide is a cardiac neurohormone that is secreted by the left ventricle in response to an increase in wall stress [2]. BNP has emerged as an important cardiac neuro-hormone with multiple potential roles in the management of patients with cardiac dysfunction, Brain natriuretic peptide (1-32) (human) is the active part of BNP [3,4].

Brain natriuretic peptide (1-32) (human) regulates the production of major inflammatory molecules, such as reactive oxygen- and nitrogen species (ROS and RNS), leukotriene B(4) (LTB(4)), prostaglandin E(2) (PGE(2)); modulates the cytokines (TNF-alpha, IL-12 and IL-10) profile, and affects cell motility[1].

In a consecutive series of 200 patients referred for echocardiographic assessment of LV function , those with normal function had substantially lower Brain natriuretic peptide (1-32) (human) levels than those with LV (systolic, diastolic or combined) dysfunction. In this population with a very high prevalence of LV dysfunction (47.5%), a Brain natriuretic peptide (1-32) (human) of 75 pg/ml or more was highly accurate at identifying such patients. In this highly selected group, BNP-32 testing appears to be a very good screening tool[5].

When evaluated the utility of Brain natriuretic peptide (1-32) (human)-guided ACE inhibitor titration compared with clinically guided titration in a small randomized trial. Comprehensive hemodynamic assessment was performed at the study onset and after 8 weeks of treatment. At study end, the ACE inhibitor dose was significantly greater (p = 0.006) and heart rate was significantly reduced (p = 0.02) in the BNP-32 group compared with the clinically guided group[6].

The utility of Brain natriuretic peptide (1-32) (human) testing to screen for systolic or diastolic dysfunction was evaluated in a substudy of the Heart and Soul study. In this group of stable out-patients with known coronary disease, an elevated BNP-32 level (>100 pg/ml) was associated with both systolic and diastolic dysfunction[7].

References:
[1]. ChiurchiÙ V, Izzi V, et,al. Brain Natriuretic Peptide (BNP) regulates the production of inflammatory mediators in human THP-1 macrophages. Regul Pept. 2008 Jun 5;148(1-3):26-32. doi: 10.1016/j.regpep.2008.02.009. Epub 2008 Mar 10. PMID: 18410972.
[2]. Wasywich CA, Whalley GA, et,al. Brain natriuretic peptide in the contemporary management of congestive heart failure. Expert Rev Cardiovasc Ther. 2005 Jan;3(1):71-84. doi: 10.1586/14779072.3.1.71. PMID: 15723576.
[3]. Sudoh T, Maekawa K, et,al. Cloning and sequence analysis of cDNA encoding a precursor for human brain natriuretic peptide. Biochem Biophys Res Commun. 1989 Mar 31;159(3):1427-34. doi: 10.1016/0006-291x(89)92269-9. PMID: 2522777.
[4]. Hunt PJ, Yandle TG, et,al. The amino-terminal portion of pro-brain natriuretic peptide (Pro-BNP) circulates in human plasma. Biochem Biophys Res Commun. 1995 Sep 25;214(3):1175-83. doi: 10.1006/bbrc.1995.2410. PMID: 7575527.
[5]. Maisel AS, Koon J, et,al. Utility of B-natriuretic peptide as a rapid, point-of-care test for screening patients undergoing echocardiography to determine left ventricular dysfunction. Am Heart J. 2001 Mar;141(3):367-74. doi: 10.1067/mhj.2001.113215. PMID: 11231433.
[6]. Murdoch DR, McDonagh TA, et,al. Titration of vasodilator therapy in chronic heart failure according to plasma brain natriuretic peptide concentration: randomized comparison of the hemodynamic and neuroendocrine effects of tailored versus empirical therapy. Am Heart J. 1999 Dec;138(6 Pt 1):1126-32. doi: 10.1016/s0002-8703(99)70079-7. PMID: 10577444.
[7]. Bibbins-Domingo K, Ansari M, et,al. Is B-type natriuretic peptide a useful screening test for systolic or diastolic dysfunction in patients with coronary disease? Data from the Heart and Soul Study. Am J Med. 2004 Apr 15;116(8):509-16. doi: 10.1016/j.amjmed.2003.08.037. PMID: 15063811; PMCID: PMC2776680.

Chemical Properties

Cas No. 124584-08-3 SDF
Chemical Name (1E,3S,4Z,6S,7Z,9S,10Z,12S,13Z,15S,16Z,18S)-18-((1H-imidazol-5-yl)methyl)-1-((4R,5E,8Z,10S,11Z,14Z,16S,17Z,19S,20Z,22S,23E,25S,26Z,28S,29Z,31S,32E,34S,35Z,37S,38E,40S,41Z,43S,44Z,47Z,49S,50Z,52R)-52-((Z)-((1Z,3S,4Z,6S,7Z,9S,10Z,12S,13Z,16Z,18S,19Z)-1-((S)
Canonical SMILES CC[C@]([C@@]1([H])/C(O)=N/[C@@](/C(O)=N\[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/C/C(O)=N/[C@@](/C(O)=N/C/C(O)=N\[C@@](/C(O)=N\[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](C(O)=O)([H])CC2=CN=CN2)([H])CCCNC(N)=N)([H])CCCNC(N
Formula C143H244N50O42S4 M.Wt 3464.05
Solubility Soluble to 24mg/ml in sterile water Storage -20°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

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1 mg 5 mg 10 mg
1 mM 0.2887 mL 1.4434 mL 2.8868 mL
5 mM 0.0577 mL 0.2887 mL 0.5774 mL
10 mM 0.0289 mL 0.1443 mL 0.2887 mL
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