Cabergoline-d6 (Synonyms: FCE-21336-d6) |
Catalog No.GC47016
One-Click Copy Product Info
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A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2738376-76-4
Sample solution is provided at 25 µL, 10mM.
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Cabergoline-d6 is intended for use as an internal standard for the quantification of cabergoline by GC- or LC-MS. Cabergoline is a dopamine D2 receptor agonist (Ki = 0.912 nM in rat striatal homogenates).1 It is selective for dopamine D2 over D1 receptors (Ki = 6,935 nM). Cabergoline inhibits prolactin secretion in, and growth of, isolated rat pituitary tumor cells in a concentration-dependent manner, an effect that can be blocked by the dopamine D2 receptor antagonist haloperidol .2 Cabergoline reduces phosphorylation of mammalian target of rapamycin (mTOR) and induces the formation of LC3 puncta, a marker of autophagy, and apoptosis in MMQ rat pituitary cells.3 In vivo, cabergoline (0.25 mg/kg) stimulates motor activity and decreases dyskinesias in a cynomolgus monkey model of Parkinson's disease induced by MPTP.4 Formulations containing cabergoline have been used in the treatment of prolactinomas.
1.Miyagi, M., Itoh, F., Taya, F., et al.Dopamine receptor affinities in vitro and stereotypic activities in vivo of cabergoline in ratsBiol. Pharm. Bull.19(9)1210-1213(1996) 2.Eguchi, K., Kawamoto, K., Uozumi, T., et al.Effect of cabergoline, a dopamine agonist, on estrogen-induced rat pituitary tumors: In vitro culture studiesEndocr. J.42(3)413-420(1995) 3.Lin, S.J., Leng, Z.G., Guo, Y.H., et al.Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergolineOncotarget6(36)39329-39341(2015) 4.Grondin, R., Goulet, M.T., Di Paolo, T., et al.Cabergoline, a long-acting dopamine D2-like receptor agonist, produces a sustained antiparkinsonian effect with transient dyskinesias in parkinsonian drug-naive primatesBrain Res.735(2)298-306(1996)
| Cas No. | 2738376-76-4 | SDF | |
| Synonyms | FCE-21336-d6 | ||
| Canonical SMILES | O=C(NCC)N(CCCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C([C@H]1CN(CC=C)[C@@]2([H])[C@](C3=C4C(C2)=CNC4=CC=C3)([H])C1)=O | ||
| Formula | C26H31D6N5O2 | M.Wt | 457.6 |
| Solubility | Acetonitrile: Soluble,DMSO: Soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.1853 mL | 10.9266 mL | 21.8531 mL |
| 5 mM | 437.1 μL | 2.1853 mL | 4.3706 mL |
| 10 mM | 218.5 μL | 1.0927 mL | 2.1853 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)