cAC 253 |
| Catalog No.GC50494 |
Amylin (AMY3) antagonist; brain penetrant
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Amylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's disease model.
Soudy et al (2016) Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease. Alzheimers Dement. (N Y) 3 44 PMID:29067318 |Mietlicki-Baase (2018) Amylin in Alzheimer's disease: Pathological peptide or potential treatment• Neuropharmacology 136 287 PMID:29233636
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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