Carazolol-d7 (Synonyms: (±)-Carazolol-d7) |
| Catalog No.GC49564 |
An internal standard for the quantification of carazolol
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1173021-02-7
Sample solution is provided at 25 µL, 10mM.
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Carazolol-d7 is intended for use as an internal standard for the quantification of carazolol by GC- or LC-MS. Carazolol is a β-adrenergic receptor (β-AR) ligand (Kds = 0.2, 0.03, and 4.47 nM for the human β1-, β2-, and β3-ARs, respectively).1 It reduces epinephrine-induced increases in mean arterial blood pressure and heart rate in conscious pigs when administered at a dose of 10 µg/kg.2 Carazolol has been found in wastewater effluent.3 Formulations containing carazolol have been used to reduce stress in livestock during transport.
1.Baker, J.G.The selectivity of β-adrenoceptor agonists at human β1-, β2- and β3-adrenoceptorsBr. J. Pharmacol.160(5)1048-1061(2010) 2.Gregory, N.G., and Wilkins, L.J.The effect of carazolol on the cardiovascular responses to adrenaline in stress sensitive pigsVet. Res. Commun.5(3)277-283(1982) 3.Ternes, T.A.Occurrence of drugs in German sewage treatment plants and riversWater Res.32(11)3245-3260(1998)
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