Methyocarbamol (Synonyms: AHR 85, Guaiacol Glyceryl Ether Carbamate, Guaiphenesin Carbamate, NSC 170960) |
| Catalog No.GC16339 |
Methyocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 532-03-6
Sample solution is provided at 25 µL, 10mM.
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Methocarbamol is a central muscle relaxant used to treat skeletal muscle spasms.Target: Carbonic AnhydraseMethocarbamol is the carbamate of guaifenesin, but does not produce guaifenesin as a metabolite, because the carbamate bond is not hydrolyzed metabolically; metabolism is by Phase I ring hydroxylation and O-demethylation, followed by Phase II conjugation. All the major metabolites are unhydrolyzed carbamates. Methocarbamol is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm [1, 2].
References:
[1]. Bruce, R.B., L.B. Turnbull, and J.H. Newman, Metabolism of methocarbamol in the rat, dog, and human. J Pharm Sci, 1971. 60(1): p. 104-6.
[2]. Sica, D.A., et al., Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol, 1990. 39(2): p. 193-4.
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