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Flavin adenine dinucleotide disodium Catalog No.GC11941

A flavin dinucleotide

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100mg
$56.00
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500mg
$219.00
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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 84366-81-4 SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES CC1=CC(N=C(C([O-])=N2)C3=NC2=O)=C(N3C[C@@](O)([H])[C@@](O)([H])[C@@](O)([H])COP([O-])(OP(O)(OC[C@](O4)([H])[C@](O)([H])[C@](O)([H])[C@]4([H])N5C=NC(C5=NC=N6)=C6N)=O)=O)C=C1C.[Na+].[Na+]
Formula C27H31N9Na2O15P2 M.Wt 829.51
Solubility ≥ 207.5mg/mL in H2O Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

Flavin Adenine Dinucleotide Disodium is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

Poly(Flavin Adenine Dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry[2].

With flavin adenine dinucleotide (2 mg/kg), the chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT) is significantly cancelled. Flavin Adenine Dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin Adenine Dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin Adenine Dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine[1].

References:
[1]. Sugiyama S, et al. Protection of chlorpromazine-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. Jpn Heart J. 1979 Sep;20(5):657-65.
[2]. Karyakin AA, et al. Electropolymerized flavin adenine dinucleotide as an advanced NADH transducer. Anal Chem. 2004 Apr 1;76(7):2004-9.