Nogalamycin (Synonyms: NSC 70845, U 15167) |
Catalog No.GC44438 |
Nogalamycin is an anthracycline originally isolated from S.
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Cas No.: 1404-15-5
Sample solution is provided at 25 µL, 10mM.
Nogalamycin is an anthracycline originally isolated from S. nogalater and a DNA-intercalating agent. It inhibits the DNA-unwinding and ATPase activities of P. falciparum DNA helicase 60 (IC50s = 2 and 0.5 μM, respectively) and the DNA cleavage activity of vaccinia virus topoisomerase (IC50 = 0.7 μM). Nogalamycin also inhibits the growth of MCF-7 and MDA-MB-231 human breast cancer cells (IC50s = 0.242 and 0.37 μM, respectively).
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