Cytidine 5'-triphosphate (sodium salt) (Synonyms: NSC 20261) |
Catalog No.GC43355
One-Click Copy Product Info
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Cytidine 5'-triphosphate (sodium salt) is an endogenous metabolite.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 36051-68-0
Sample solution is provided at 25 µL, 10mM.
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Cytidine 5'-triphosphate (CTP) is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases. In the formation of phosphatidylcholine (PC), CTP reacts with phosphocholine, via CTP:phosphocholine cytidylyltransferases, to produce CDP-choline and diphosphate.[1],[2] This is the rate-limiting step in PC synthesis and, as a pivotal step in cell proliferation, can be important in cancer.[3] CTP also interacts with N-acylneuraminate, in a reaction mediated by N-acylneuraminate cytidylyltransferase, to generate an intermediate that is required for sialylation, namely CMP-N-acylneuraminic acid.[4]
Reference:
[1]. Li, Z., and Vance, D.E. Phosphatidylcholine and choline homeostasis. Journal of Lipid Research 49, 1187-1194 (2008).
[2]. Lagace, T.A., and Ridgway, N.D. The role of phospholipids in the biological activity and structure of the endoplasmic reticulum. Biochim.Biophys.Acta. 1833, 2499-2510 (2013).
[3]. Arsenault, D.J., Yoo, B.H., Rosen, K.V., et al. ras-Induced up-regulation of CTP:phosphocholine cytidyltransferase a contributes to malignant transformation of intestinal epithelial cells. The Journal of Biological Chemisty 288(1), 633-643 (2013).
[4]. Vionnet, J., Concepcion, N., Warner, T., et al. Purification of CMP-N-acetylneuraminic acid synthetase from bovine anterior pituitary glands. Glycobiology 9(5), 481-487 (1999).
| Cas No. | 36051-68-0 | SDF | |
| Synonyms | NSC 20261 | ||
| Chemical Name | cytidine 5'-(tetrahydrogen triphosphate), disodium salt | ||
| Canonical SMILES | O=P(OP(OP(O)([O-])=O)([O-])=O)(O)OC[C@H]1O[C@@H](N2C(N=C(N)C=C2)=O)[C@H](O)[C@@H]1O.[Na+].[Na+] | ||
| Formula | C9H14N3O14P3 • 2Na | M.Wt | 527.1 |
| Solubility | H2O : 100 mg/mL (189.71 mM; Need ultrasonic); DMSO : < 1 mg/mL (insoluble or slightly soluble) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.8972 mL | 9.4859 mL | 18.9717 mL |
| 5 mM | 379.4 μL | 1.8972 mL | 3.7943 mL |
| 10 mM | 189.7 μL | 948.6 μL | 1.8972 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)