CE-245677 |
| Catalog No.GC32623 |
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 717899-97-3
Sample solution is provided at 25 µL, 10mM.
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CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, and displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR[1].
CE-245677 shows good oral absorption in in vivo rat PK studies (F=80%)[1].
[1]. Susan LaGreca, et al. Identification of selective, orally active Tie2 kinase inhibitors and discovery of CE-245,677 and PF-371,989. Cancer Research. AACR Annual Meeting-Apr 14-18, 2007.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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