CGRP (8-37) (mouse, rat) (trifluoroacetate salt) (Synonyms: Calcitonin Gene-Related Peptide (8-37), CGRP8-37, VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2)

Name: CGRP (8-37) (mouse, rat) (trifluoroacetate salt)
Brand: GlpBio
SKU: GC52438
Availability: InStock
Rating: 5 (30 reviews)

Catalog No.GC52438

A CGRP receptor antagonist

Products are for research use only. Not for human use. We do not sell to patients.

CGRP (8-37) (mouse, rat) (trifluoroacetate salt) Chemical Structure

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500 μg	$461.00	In stock
1 mg	$736.00	In stock
5 mg	$1,498.00	In stock

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Sample solution is provided at 25 µL, 10mM.

GlpBio Products Cited In Reputable Papers

Nature
610.7931 (2022): 366-372

Nature
618, 1017–1023 (2023)

Cell
183.7 (2020): 1867-1883

Cell Research
31, 1291–1307 (2021)

Cell Research
33, 273–287 (2023)

Cell Research
33, 546–561 (2023)

Molecular Cancer
21.1 (2022): 1-17

Molecular Cancer
21.1 (2022): 1-18

Cancer Cell
39 (2021): 1-16

Cell Host Microbe
30.8 (2022): 1124-1138

Cell Host Microbe
31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

Description Chemical Properties Product Documents

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Purity: >95.00%

Calcitonin gene-related protein (CGRP) (8-37) is a CGRP receptor antagonist.¹ It corresponds to amino acids 8-37 of rodent α-CGRP , a neuropeptide. CGRP (8-37) selectively binds to heterotrimeric complexes of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1) or RAMP3 (IC₅₀s = 1 and 6.2 nM, respectively) over a complex of CRLR and RAMP2 (IC₅₀ = 219 nM). It prevents CGRP-induced increases in heart rate and decreases in blood pressure in transgenic mice expressing rat CRLR in smooth muscle-containing tissues and sympathetic ganglia when administered at a dose of 2 µmol/kg.² CGRP (8-37) also inhibits p-phenylquinone-induced writhing (ED₅₀ = 6 µg/animal) and decreases body temperature in a dose-dependent manner in mice.³

1.Husmann, K., Born, W., Fischer, J.A., et al.Three receptor-activity-modifying proteins define calcitonin gene-related peptide or adrenomedullin selectivity of the mouse calcitonin-like receptor in COS-7 cellsBiochem. Pharmacol.66(11)2107-2115(2003) 2.Kunz, T.H., Scott, M., Ittner, L.M., et al.Calcitonin gene-related peptide-evoked sustained tachycardia in calcitonin receptor-like receptor transgenic mice is mediated by sympathetic activityAm. J. Physiol. Heart Circ. Physiol.293(4)H2155-H2160(2007) 3.Saxen, M.A., Smith, F.L., Dunlow, L.D., et al.The hypothermic and antinociceptive effects of intrathecal injection of CGRP (8-37) in miceLife Sci.55(21)1665-1674(1994)

Cas No.		SDF	Download SDF
Synonyms	Calcitonin Gene-Related Peptide (8-37), CGRP8-37, VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2
Canonical SMILES	OC(C(F)(F)F)=O.CC(C)[C@H](N[H])C(N[C@]([C@H](O)C)([H])C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN[H])C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N2CCC[C@H]2C(N[C@]([C@H](O)C)([H])C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N)=O)CC3=CC=CC=C3)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)C)=O)CC(C)C)=O)=O)=O)=O
Formula	C138H224N42O41 ? XCF3COOH	M.Wt	3127.5
Solubility	PBS (pH 7.2): 2 mg/ml	Storage	-20°C
General tips	Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition	Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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		1 mg	5 mg	10 mg
	1 mM	0.3197 mL	1.5987 mL	3.1974 mL
	5 mM	0.0639 mL	0.3197 mL	0.6395 mL
	10 mM	0.032 mL	0.1599 mL	0.3197 mL

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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CGRP (8-37) (mouse, rat) (trifluoroacetate salt) (Synonyms: Calcitonin Gene-Related Peptide (8-37), CGRP8-37, VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2)

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