Thalidomide-propargyl |
| Katalog-Nr.GC38862 |
Thalidomid-Propargyl ist der Thalidomid-basierte Cereblon-Ligand, der bei der Rekrutierung des CRBN-Proteins verwendet wird. Thalidomid-Propargyl kann mit dem Liganden fÜr Protein durch einen Linker verbunden werden, um das IMiD zu bilden, das PROTACs enthÄlt.
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Cas No.: 2098487-39-7
Sample solution is provided at 25 µL, 10mM.
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Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs[1].
[1]. Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.
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