DL-AP5 (Synonyms: DL-2-Amino-5-Phosphonovaleric acid，2-APV) |
| Catalog No.GC17206 |
A NMDA antagonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 76326-31-3
Sample solution is provided at 25 µL, 10mM.
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DL-AP5 is the racemic version of the selective N-methyl-D-aspartate (NMDA) receptor antagonist, D-AP5 .[1] Whereas D-AP5 is the active (−)-stereoisomer that competitively inhibits the glutamate binding site of NMDA receptors (Kd = 1.4 μM), the (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity.1 AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.[2]
Reference:
[1]. Evans, R.H., Francis, A.A., Jones, A.W., et al. The effects of a series of ω-phosphonic α-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br. J. Pharmacol. 75(1), 65-75 (1982).
[2]. Morris, R.J. Synaptic plasticity and learning: Selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. J. Neurosci. 9(9), 3040-3057 (1989).
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