Home>>DM1-SMe
DM1-SMe Catalog No.GC18254

Size Price Stock Qty
1mg
$36.00
In stock
5mg
$162.00
In stock
10mg
$286.00
In stock
25mg
$628.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Quality Control

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Chemical Properties

Cas No. 138148-68-2 SDF Download SDF
Synonyms N/A
Chemical Name N2'-deacetyl-N2'-[3-(methyldithio)-1-oxopropyl]-maytansine
Canonical SMILES C[C@@]1([C@@H](O1)[C@H](C)[C@]([H])(C[C@](N2)(O)[C@]([H])(OC)/C=C/C=C(CC3=CC(OC)=C(Cl)C4=C3)\C)OC2=O)[C@@]([H])(OC([C@@H](N(C)C(CCSSC)=O)C)=O)CC(N4C)=O
Formula C36H50ClN3O10S2 M.Wt 784.4
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

DM1-SMe is an analog of mertansine with a thiomethane cap attached to the sulfhydryl group. It has in vitro activity against the pediatric preclinical testing program (PPTP) panel of cancer cell lines with IC50 values of 0.002 to >3 nM.

References:

[1]. Wood, A.C., Maris, J.M., Gorlick, R., et al. Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program Pediatr. Blood Cancer 60(11), 1860-1867 (2013).