Echinacoside
Catalog No.: GN10422Purity:>98.00%Synonyms: Kusaginin, NSC 603831, trans-Acteoside, trans-Verbascoside
Echinacoside is a phenylethanoid glycoside isolated from Cistanche tubulosa with potent antioxidant and anti-inflammatory effects.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 82854-37-3
10mM (in 1mL DMSO)In Stock
$29.00
1
5mgIn Stock
$22.00
1
10mgIn Stock
$34.00
1
25mgIn Stock
$64.00
1
50mgIn Stock
$101.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $29.00 | In Stock | 1 | |
| 5mg | $22.00 | In Stock | 1 | |
| 10mg | $34.00 | In Stock | 1 | |
| 25mg | $64.00 | In Stock | 1 | |
| 50mg | $101.00 | In Stock | 1 |
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Citations
1 publicationsPublications from researchers using this productDescription
Echinacoside is a phenylethanoid glycoside isolated from Cistanche tubulosa with potent antioxidant and anti-inflammatory effects[1]. Echinacoside is commonly used in research on neurodegenerative diseases (Parkinson's disease, Alzheimer's disease), cardiovascular health, and skin protective agents[2,3,4].
In vitro, Echinacoside (20, 50, 100μg/mL) treatment of HepG2 cells for 24, 48, and 72h inhibited cell proliferation in a concentration- and time-dependent manner and induced apoptosis. Echinacoside (50, 100μg/mL) treatment of HepG2 cells for 48h significantly reduced p-AKT protein levels and upregulated the protein expression of p21 and Bax[5]. Echinacoside (0.1, 1, 10nM) treatment of MC3T3-E1 cells for 21 days dose-dependently and significantly promoted mineralized nodule formation[6].
In vivo, intragastric administration of Echinacoside (30, 90, 270mg/kg/day) to ovariectomized rats for 12 weeks significantly increased osteoprotegerin levels and decreased receptor activator of nuclear factor-κB ligand (RANKL) levels[7]. A single oral dose of Echinacoside (250, 500mg/kg) administered to starch-loaded mice significantly inhibited the postprandial increase in blood glucose levels, with blood glucose levels in the 500mg/kg dose group being significantly lower than those in the control group at 0.5, 1, and 2h[8].
References:
[1] LIU J, YANG L, DONG Y, et al. Echinacoside, an inestimable natural product in treatment of neurological and other disorders[J]. Molecules, 2018, 23(5): 1213.
[2] LI J, YU H, YANG C, et al. Therapeutic potential and molecular mechanisms of echinacoside in neurodegenerative diseases[J]. Frontiers in Pharmacology, 2022, 13: 841110.
[3] SHEOKAND A, KOLI D, WADHWA K, et al. Mechanistic insights into the anticancer potential of echinacoside: therapeutic applications and future directions[J]. Archiv der Pharmazie, 2025, 358(11): e70153.
[4] LI L, RAN Y, WEN J, et al. Traditional Chinese medicine-based treatment in cardiovascular disease: potential mechanisms of action[J]. Current Pharmaceutical Biotechnology, 2024, 25(17): 2186-2199.
[5] YE Y, SONG Y, ZHUANG J, et al. Anticancer effects of echinacoside in hepatocellular carcinoma mouse model and HepG2 cells[J]. Journal of Cellular Physiology, 2019, 234(2): 1880-1888.
[6] LI F, YANG Y, ZHU P, et al. Echinacoside promotes bone regeneration by increasing OPG/RANKL ratio in MC3T3-E1 cells[J]. Fitoterapia, 2012, 83(8): 1443-1450.
[7] WU L, GEORGIEV M I, CAO H, et al. Therapeutic potential of phenylethanoid glycosides: a systematic review[J]. Medicinal Research Reviews, 2020, 40(6): 2605-2649.
[8] MORIKAWA T, NINOMIYA K, IMAMURA M, et al. Acylated phenylethanoid glycosides, echinacoside and acteoside from Cistanche tubulosa, improve glucose tolerance in mice[J]. Journal of Natural Medicines, 2014, 68(3): 561-566.
Protocol
| Cell experiment [1]: | |
Cell lines | HepG2 cells |
Preparation Method | HepG2 cells were exposed to various doses of Echinacoside (50, 100μg/mL). After 48h, the western blot analysis was performed to assess the expression of p‐AKT, p21, and Bax. |
Reaction Conditions | 50, 100μg/mL; 48h |
Applications | Treatment of Echinacoside significantly reduced p-AKT protein levels and upregulated p21 and Bax protein expression. |
| Animal experiment [2]: | |
Animal models | Starch-loaded ddY mice |
Preparation Method | A mixture of Echinacoside (250, 500mg/kg) and α-starch (1g/kg) suspended in 5% (w/v) acacia solution was administered orally to fasted mice. Blood samples were collected from the infraorbital venous plexus under ether anesthesia at 0.5, 1, and 2h after oral administration, and plasma glucose levels were determined enzymatically by the Glucose CII test Wako. |
Dosage form | 250, 500mg/kg; p.o. |
Applications | Treatment of Echinacoside significantly inhibited the rise in postprandial blood glucose in starch-loaded mice, with blood glucose levels at 0.5h, 1h, and 2h significantly lower than those in the control group at a dose of 500mg/kg. |
References: | |
Product Documents
Purity:>98.00%Appearance:A solid
Chemical Properties
CAS No.
82854-37-3
Synonyms
Kusaginin, NSC 603831, trans-Acteoside, trans-Verbascoside
Chemical Name
[(2R,3R,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-2-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
SMILES
CC1C(C(C(C(O1)OC2C(C(OC(C2OC(=O)C=CC3=CC(=C(C=C3)O)O)COC4C(C(C(C(O4)CO)O)O)O)OCCC5=CC(=C(C=C5)O)O)O)O)O)O
Molecular Formula
C35H46O20
Molecular Weight
786.72
Solubility
≥ 78.7mg/mL in DMSO
Storage
Store at 2-8°C, protect from light
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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