Etoposide-d3 (Synonyms: EPE-d3, VP-16-123-d3) |
| Catalog No.GC40195 |
Etoposide-d3 is intended for use as an internal standard for the quantification of etoposide by GC- or LC-MS.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Etoposide-d3 is intended for use as an internal standard for the quantification of etoposide by GC- or LC-MS. Etoposide is a plant alkaloid and an inhibitor of topoisomerase II (IC50 = 60.3 μM). It inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 µM) and human umbilical vein endothelial (HUVEC) cells (IC50 = 0.249 µM). It reduces tumor growth in an Ma human embryonal carcinoma mouse xenograft model when administered at a dose of 25 mg/kg, an effect that is enhanced by concomitant administration of the immunosuppressant cyclosporin A . Etoposide also inhibits nuclear receptor coactivator 3 (IC50 = 2.48 µM). Formulations containing etoposide have been used in combination therapy in the treatment of cancer.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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