Galanin (2-11) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) (Synonyms: AR-M1896, Gal(2-11)-NH2, WTLNSAGYLL-NH2) |
Catalog No.GC49154
One-Click Copy Product Info
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A synthetic peptide fragment of galanin and an agonist of the GAL2 receptor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Galanin (2-11) amide is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL2) receptor (EC50 = 9.32 nM in a fluorescence imaging plate reader assay).1 It selectively binds to the GAL2 receptor (IC50 = 1.76 nM for the rat receptor) over the GAL1 receptor (IC50 = 879 nM for the human receptor) but does also bind to the GAL3 receptor (Ki = 271 nM for the rat receptor).1,2 Intracerebroventricular administration of galanin (2-11) amide (1 nmol/animal) decreases immobility in the forced swim test in rats.3 It also reduces the hind paw mechanical pain threshold and increases the hind paw cold sensitivity threshold in rats.1
1.Liu, H.-X., Brumovsky, P., Schmidt, R., et al.Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: Selective actions via GalR1 and GalR2 receptorsProc. Natl. Acad. Sci. USA98(17)9960-9964(2001) 2.Lu, X., LundstrÖm, L., and Bartfai, T.Galanin (2-11) binds to GalR3 in transfected cell lines: Limitations for pharmacological definition of receptor subtypesNeuropeptides39(3)165-167(2005) 3.Kuteeva, E., Wardi, T., LundstrÖm, L., et al.Differential role of galanin receptors in the regulation of depression-like behavior and monoamine/stress-related genes at the cell body levelNeuropsychopharmacology33(11)2573-2585(2008)
| Cas No. | N/A | SDF | |
| Synonyms | AR-M1896, Gal(2-11)-NH2, WTLNSAGYLL-NH2 | ||
| Canonical SMILES | N[C@H](C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](C)C(NCC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CC(C)C)=O)=O)CC(C=C1)=CC=C1O)=O)=O)=O)=O)=O)=O)=O)CC2=CNC3=CC=CC=C23.OC(C(F)(F)F)=O | ||
| Formula | C54H81N13O14·XCF3COOH | M.Wt | 1136.3 |
| Solubility | DMF: 5 mg/ml,DMSO: 5 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 880 μL | 4.4002 mL | 8.8005 mL |
| 5 mM | 176 μL | 880 μL | 1.7601 mL |
| 10 mM | 88 μL | 440 μL | 880 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)