Hydroxocobalamin acetate |
Catalog No.GC36274
One-Click Copy Product Info
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Hydroxocobalamin acetate is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the research of vitamin B12 deficiency including pernicious anemia.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 22465-48-1
Sample solution is provided at 25 µL, 10mM.
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Hydroxocobalamin acetate is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia[1][2]. The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide (NO) and hydroxocobalamin attenuates vascular responses to NO in vitro[3].
[1]. Cheungpasitporn W, et al. High-dose hydroxocobalamin for vasoplegic syndrome causing false blood leak alarm. Clin Kidney J. 2017 Jun;10(3):357-362. [2]. Wang H, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2018 Mar 15;3:CD004655. [3]. Greenberg SS, et al. Hydroxocobalamin (vitamin B12a) prevents and reverses endotoxin-induced hypotension and mortality in rodents: role of nitric oxide. J Pharmacol Exp Ther. 1995 Apr;273(1):257-65.
| Cas No. | 22465-48-1 | SDF | |
| Canonical SMILES | CC12[N]([Co+3]34([N-]5C2C(CC(N)=O)C(C)(CCC(NCC(C)O6)=O)C5=C(C)C(C(CCC(N)=O)C7(C)C)=[N]3C7=CC8=[N]4C(C(CC(N)=O)(C)C8CCC(N)=O)=C9C)([N]%10=CN(C(OC(CO)C%11OP6([O-])=O)C%11O)C%12=C%10C=C(C)C(C)=C%12)[O-]C(C)=O)=C9C(CCC(N)=O)C1(C)CC(N)=O | ||
| Formula | C64H91CoN13O16P | M.Wt | 1388.39 |
| Solubility | DMSO : 100 mg/mL (71.15 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 720.3 μL | 3.6013 mL | 7.2026 mL |
| 5 mM | 144.1 μL | 720.3 μL | 1.4405 mL |
| 10 mM | 72 μL | 360.1 μL | 720.3 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)