Dimethyl lithospermate B |
| Catalog No.GC38484 |
Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 875313-64-7
Sample solution is provided at 25 µL, 10mM.
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Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP)[1][2].
[1]. Fish JM, et al. Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome. Circulation. 2006 Mar 21;113(11):1393-400. [2]. Yoon JY, et al. A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes. Br J Pharmacol. 2004 Nov;143(6):765-73.
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