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ATI-2341 TFA Catalog No.GC38541

Size Price Stock Qty
10mM*1mL in DMSO
$1,622.00
In stock
1mg
$143.00
In stock
5mg
$398.00
In stock
10mg
$622.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. N/A SDF Download SDF
Synonyms N/A
Chemical Name N/A
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Formula C106H179F3N26O27S2 M.Wt 2370.84
Solubility DMSO: 100 mg/mL (42.18 mM) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs)[1][2].

CXCR4[1]

[1]. Quoyer J, et al. Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5088-97. [2]. Tchernychev B, et al. Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22255-9.