Talatisamine |
Catalog No.GC45573
One-Click Copy Product Info
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Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 20501-56-8
Sample solution is provided at 25 µL, 10mM.
Talatisamine is a diterpene alkaloid originally isolated from A. talassicum and has diverse biological activities.1,2,3,4,5 It blocks delayed rectifier potassium (IK) current in rat hippocampal neurons (IC50 = 146 μM).3 Talatisamine reduces increases in IK current and cytotoxicity in primary rat cortical neurons induced by amyloid-β (1-40) .4 It inhibits barium chloride-induced contractions in isolated rat intenstines (EC50 = 200 μM).2 Talatisamine exhibits feeding deterrent activity against red flour beetle (T. castaneum) adults (EC50 = 342.8 ppm).5
References
1. Konovalova, R.A., and Orekhov, A.P. Aconite alkaloids. I. Alkaloids of aconitum talassicum. B. Soc. Chim. Fr. 7, 95-105 (1940).
2. Dzhakhangirov, F.N., Tursunkhodzhaeva, F.M., Sultankhodzhaev, M.N., et al. Spasmolytic activity of diterpenoid alkaloids and their derivatives. Structure-activity relationship. Chem. Nat. Compd. 49(4), 702-706 (2013).
3. Song, M.K., Liu, H., Jiang, H.L., et al. Discovery of talatisamine as a novel specific blocker for the delayed rectifier K+ channels in rat hippocampal neurons. Neuroscience 155(2), 469-475 (2008).
4. Wang, Y., Song, M., Hou, L., et al. The newly identified K+ channel blocker talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons. Neurosci. Lett. 518(2), 122-127 (2012).
5. Liu, Z.L., Cao, J., Zhang, H.M., et al. Feeding deterrents from Aconitum episcopale roots against the red flour beetle, Tribolium castaneum. J. Agric. Food Chem. 59(8), 3701-3706 (2011).
| Cas No. | 20501-56-8 | SDF | |
| Canonical SMILES | [H][C@]1(C2)C([C@@H](OC)CC[C@]34COC)(C5N(CC)C4)[C@]3([H])CC5[C@]6(O)[C@@]1([H])[C@@H](O)[C@@]2([H])[C@@H](OC)C6 | ||
| Formula | C24H39NO5 | M.Wt | 421.6 |
| Solubility | DMF: 1mg/mL,DMSO: 2 mg/mL,Ethanol: 10mg/mL | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3719 mL | 11.8596 mL | 23.7192 mL |
| 5 mM | 474.4 μL | 2.3719 mL | 4.7438 mL |
| 10 mM | 237.2 μL | 1.186 mL | 2.3719 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)