Talatisamine

Talatisamine is a diterpene alkaloid originally isolated from A. talassicum and has diverse biological activities.1,2,3,4,5 It blocks delayed rectifier potassium (IK) current in rat hippocampal neurons (IC50 = 146 μM).3 Talatisamine reduces increases in IK current and cytotoxicity in primary rat cortical neurons induced by amyloid-β (1-40) .4 It inhibits barium chloride-induced contractions in isolated rat intenstines (EC50 = 200 μM).2 Talatisamine exhibits feeding deterrent activity against red flour beetle (T. castaneum) adults (EC50 = 342.8 ppm).5

References
1. Konovalova, R.A., and Orekhov, A.P. Aconite alkaloids. I. Alkaloids of aconitum talassicum. B. Soc. Chim. Fr. 7, 95-105 (1940).
2. Dzhakhangirov, F.N., Tursunkhodzhaeva, F.M., Sultankhodzhaev, M.N., et al. Spasmolytic activity of diterpenoid alkaloids and their derivatives. Structure-activity relationship. Chem. Nat. Compd. 49(4), 702-706 (2013).
3. Song, M.K., Liu, H., Jiang, H.L., et al. Discovery of talatisamine as a novel specific blocker for the delayed rectifier K+ channels in rat hippocampal neurons. Neuroscience 155(2), 469-475 (2008).
4. Wang, Y., Song, M., Hou, L., et al. The newly identified K+ channel blocker talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons. Neurosci. Lett. 518(2), 122-127 (2012).
5. Liu, Z.L., Cao, J., Zhang, H.M., et al. Feeding deterrents from Aconitum episcopale roots against the red flour beetle, Tribolium castaneum. J. Agric. Food Chem. 59(8), 3701-3706 (2011).