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Tyramine-d4 (hydrochloride) (Synonyms: 2-(4-Hydroxyphenyl)ethylamine-d4, p-Tyramine-d4, Uteramine-d4)

Catalog No.GC45587

 

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Tyramine-d4 (hydrochloride) Chemical Structure

Cas No.: 1189884-47-6

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5mg
$547.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Tyramine-d4 is intended for use as an internal standard for the quantification of tyramine by GC- or LC-MS. Tyramine is a tyrosine-derived endogenous and dietary monoamine and trace amine-associated receptor 1 (TAAR1) agonist.1,2,3 It activates TAAR1 (EC50s = 0.08, 0.69, and 2.26 μM for rat, mouse, and human-rat chimera receptors, respectively).1 Tyramine also inhibits the release of norepinephrine and dopamine in isolated rat caudate nucleus (IC50s = 40.6 and 119 nM, respectively).4

References
1. Reese, E.A., Bunzow, J.R., Arttamangkul, S., et al. Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine. J. Pharmacol. Exp. Ther. 321(1), 178-186 (2007).
2. Zucchi, R., Chiellini, G., Scanlan, T.S., et al. Trace amine-associated receptors and their ligands. Br. J. Pharmacol. 149(8), 967-978 (2006).
3. Maguire, J.J., Parker, W.A.E., Foord, S.M., et al. International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. Pharmacol. Rev. 61(1), (2009).
4. Rothman, R.B., Baumann, M.H., Dersch, C.M., et al. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Science 39(1), 32-41 (2001).

Chemical Properties

Cas No. 1189884-47-6 SDF
Synonyms 2-(4-Hydroxyphenyl)ethylamine-d4, p-Tyramine-d4, Uteramine-d4
Canonical SMILES OC1=CC=C(C([2H])([2H])C([2H])([2H])N)C=C1.Cl
Formula C8H7D4NO.HCl M.Wt 177.7
Solubility DMSO: slightly soluble,Methanol: slightly soluble,Water: slightly soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 5.6275 mL 28.1373 mL 56.2746 mL
5 mM 1.1255 mL 5.6275 mL 11.2549 mL
10 mM 0.5627 mL 2.8137 mL 5.6275 mL
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