Genkwanin (Synonyms: Apigenin 7-methyl ether, 7-Methylapigenin, Puddumetin) |
Catalog No.GN10160
One-Click Copy Product Info
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Genkwanin is a non-glycosylated flavone and is found and extracted from plant matrices.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 437-64-9
Sample solution is provided at 25 µL, 10mM.
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Genkwanin is a non-glycosylated flavone and is found and extracted from plant matrices[1]. Genkwanin possesses various biological activities, such as antioxidant, neuroprotective, anticancer, anti-bacterial and antidiabetic activities, it can effectively counteract pro-inflammatory mediators, including TNF-α, IL-1β, IFN-γ, and IL-6 cytokines[1,2].
Genkwanin (0, 12.5, 25 and 50μM; 2h) suppressed the productions of TNF-α, IL-1β and IL-6 in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages in a concentration-dependent manner[3]. Genkwanin (10μM; 72h) promoted CD8+ T cell proliferation[4].
Genkwanin (20mg/kg; 6 weeks; i.p.) alleviated airway epithelial cell damage in newborn Balb/c mice with asthma[5]. Genkwanin (10mg/kg; 7d; s.c.) protected LPS-induced osteoclast-mediated bone loss in C57BL/6 mice[6].
References:
[1] El Menyiy N, Aboulaghras S, Bakrim S, et al. Genkwanin: an emerging natural compound with multifaceted pharmacological effects [J]. Biomedicine & pharmacotherapy, 2023, 165: 115159.
[2] Sun Y W, Bao Y, Yu H, et al. Anti-rheumatoid arthritis effects of flavonoids from Daphne genkwa [J]. International immunopharmacology, 2020, 83: 106384.
[3] Gao Y, Liu F, Fang L, et al. Genkwanin inhibits proinflammatory mediators mainly through the regulation of miR-101/MKP-1/MAPK pathway in LPS-activated macrophages [J]. PloS one, 2014, 9(5): e96741.
[4] Zhang B, Fu D, Wang X, et al. Network-based analysis and experimental validation of identified natural compounds from Yinchen Wuling San for acute myeloid leukemia [J]. Frontiers in pharmacology, 2025, 16: 1591164.
[5] Chen X, Liu J, An Z, et al. Genkwanin reduces airway epithelial cell ferroptosis and alleviates asthma symptoms in mice [J]. Phytomedicine, 2025, 148: 157306.
[6] Fu X, Sun X, Zhang C, et al. Genkwanin prevents lipopolysaccharide-induced inflammatory bone destruction and ovariectomy-induced bone loss [J]. Frontiers in nutrition, 2022, 9: 921037.
| Cell experiment [1]: | |
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Cell lines |
RAW264.7 macrophages |
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Preparation Method |
RAW264.7 macrophages were pretreated with Genkwanin for 2h and then stimulated with LPS (10ng/mL) for 24h. TNF-α, IL-1β, IFNγ, and IL-6 in the cell supernatants were assayed using ELISA kits. |
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Reaction Conditions |
0, 12.5, 25 and 50μM; 2h |
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Applications |
Genkwanin suppressed the productions of TNF-α, IL-1β and IL-6 in a concentration-dependent manner. |
| Animal experiment [2]: | |
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Animal models |
Newborn Balb/c mice |
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Preparation Method |
Mice were received HDM (house dust mite) nasal administration at 3 days of age, with 10µg of HDM thrice a week for 2 weeks and 15µg of HDM thrice a week for 4 weeks. Treatment with Genkwanin was initiated 30min before the first HDM stimulation via intraperitoneal injection at doses of 20mg/kg and repeated every day until the endpoint. Apoptosis of airway epithelial cells in mouse lung tissues was analyzed using the TUNEL apoptosis detection kit. |
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Dosage form |
20mg/kg; 6 weeks; i.p. |
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Applications |
Genkwanin alleviated airway epithelial cell damage. |
References: [1] Gao Y, Liu F, Fang L, et al. Genkwanin inhibits proinflammatory mediators mainly through the regulation of miR-101/MKP-1/MAPK pathway in LPS-activated macrophages [J]. PloS one, 2014, 9(5): e96741. [2] Chen X, Liu J, An Z, et al. Genkwanin reduces airway epithelial cell ferroptosis and alleviates asthma symptoms in mice [J]. Phytomedicine, 2025, 148: 157306. | |
| Cas No. | 437-64-9 | SDF | |
| Synonyms | Apigenin 7-methyl ether, 7-Methylapigenin, Puddumetin | ||
| Chemical Name | 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychromen-4-one | ||
| Canonical SMILES | COC1=CC(=C2C(=C1)OC(=CC2=O)C3=CC=C(C=C3)O)O | ||
| Formula | C16H12O5 | M.Wt | 284.26 |
| Solubility | DMSO : 31.25 mg/mL (109.93 mM; Need ultrasonic) | Storage | 4°C, protect from light |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.5179 mL | 17.5895 mL | 35.1791 mL |
| 5 mM | 703.6 μL | 3.5179 mL | 7.0358 mL |
| 10 mM | 351.8 μL | 1.759 mL | 3.5179 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)