Glutaurine (Synonyms: γ-Glutamyl Taurine, γ-Glutamyltaurine, γ-GT, γ-L-Glutamyltaurine) |
Catalog No.GC62992
One-Click Copy Product Info
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Glutaurine, a bioactive dipeptide isolated from the bovine parathyroid gland, antagonizes cortison and thyroxin.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 56488-60-9
Sample solution is provided at 25 µL, 10mM.
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Glutaurine, a bioactive dipeptide isolated from the bovine parathyroid gland, antagonizes cortison and thyroxin [1]. Glutaurine acts as endogenous modulator in excitatory aminoacidergic neurotransmission and affects the concentration of monoamine neurotransmitters in the brain[2]. Glutaurine has been widely used to promote thymic culture growth and promote macrophage activation[3].
In vivo, Glutaurine treatment via daily oral administration at a dose of 2µg/100g for 7 days resulted in a significant reduction of the hepatic and renal tissue uric acid levels in Tetra-B chicks [4]. Oral administration of a daily dose of 2µg/kg of Glutaurine for 4 days resulted in a significant increase in DNA synthesis in the spleen of CFLB mice without affecting mouse body weight[5]. Glutaurine (50μg/rat; p.o.) effectively restored the latency of entry in the 24 test at the dose of 50μg/rat[6]. Glutaurine (3mg/kg; i.p.) dramatically decreased T3 blood levels without significantly raising T4 blood levels[7].
References:
[1] Feuer L, Katalin S. Effect of litoralon, taurine and other taurine derivatives on the heart muscle cell membrane of the locusta migratoria (migratoriodes RF)[J]. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1981, 69(2): 411-414.
[2] Bittner S, Win T, Gupta R. γ-L-glutamyltaurine[J]. Amino Acids, 2005, 28(4): 343-356.
[3] Feuer L, Török O, Csaba G. Effect of glutaurine, a newly discovered parathyroid hormone on rat thymus cultures[J]. Acta Morphologica Academiae Scientiarum Hungaricae, 1978, 26(2): 87-94.
[4] Feuer L, Tóth B L, Bárdos L. Effect of glutaurine (γ-l-glutamyl-taurine) on serum, hepatic, and renal uric acid levels[J]. Biochemical medicine, 1981, 26(3): 326-329.
[5] Antoni F, Feuer L, Hrabák A, et al. The effect of carrageenan and glutaurine on DNA synthesis of spleen cells in CFLB mice[J]. Biochemical medicine, 1979, 22(2): 238-245.
[6] Feuer L, Török O, Csaba G. Effect of glutaurine, a newly discovered parathyroid hormone on rat thymus cultures[J]. Acta Morphologica Academiae Scientiarum Hungaricae, 1978, 26(2): 87-94.
[7] Baskin S, Bartuska D, Thampi N, et al. The effect of glutaurine on thyroid hormones in the rat[J]. Neuropeptides, 1987, 9(1): 45-50.
| Animal experiment [1]: | |
Animal models | Tetra-B chicks |
Preparation Method | Tetra-B chicks, age 7 weeks, maintained on standard poultry food, were divided into 2 subgroups and treated daily with 2µg/100g of Glutaurine, dissolved in 0.5ml of tap water. The control group received only 0.5ml of tap water. After 1 week of treatment (at 8 weeks of age) the chicks were bled and their serum uric acid levels were determined. After bleeding, the liver and the kidneys were removed, and tissue samples of about 1g were taken for the determination of uric acid level. |
Dosage form | 2µg/100g/day for 1 week; p.o. |
Applications | Glutaurine treatment resulted in a significant reduction of the hepatic and renal tissue uric acid levels. |
References: | |
| Cas No. | 56488-60-9 | SDF | |
| Synonyms | γ-Glutamyl Taurine, γ-Glutamyltaurine, γ-GT, γ-L-Glutamyltaurine | ||
| Formula | C7H14N2O6S | M.Wt | 254.26 |
| Solubility | Water : 125 mg/mL (491.62 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.933 mL | 19.6649 mL | 39.3298 mL |
| 5 mM | 786.6 μL | 3.933 mL | 7.866 mL |
| 10 mM | 393.3 μL | 1.9665 mL | 3.933 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)