GSK106 (hydrochloride) |
| Catalog No.GC43787 |
GSK106 (hydrochloride) is an inactive control for the selective PAD4 inhibitors, GSK484 and GSK199.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1652591-82-6
Sample solution is provided at 25 µL, 10mM.
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Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases. GSK106 is an inactive control for the selective PAD4 inhibitors, GSK484 and GSK199 . It does not inhibit PAD4 nor does it prevent the citrullination of PAD4 target proteins or the formation of neutrophil extracellular traps in mouse or human neutrophils (IC50s > 100 µM). See the Structural Genomics Consortium (SGC) website for more information on both GSK484 and GSK106.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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