L-Leu-AMC (hydrochloride) (Synonyms: Leu-MCA, L-Leucine-7-amido-4-methylcoumarin, 7-L-Leucyl-4-methylcoumarinylamide) |
| Catalog No.GC49205 |
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 62480-44-8
Sample solution is provided at 25 µL, 10mM.
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L-Leu-AMC is a fluorogenic substrate for leucine aminopeptidase.1 Upon enzymatic cleavage by leucine aminopeptidase, AMC is released and its fluorescence can be used to quantify leucine aminopeptidase activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.
1.Izquierdo, M., Lin, D., O’Neill, S., et al.Development of a high-throughput screening assay to identify inhibitors of the major M17-leucyl aminopeptidase from Trypanosoma cruzi using rapidfire mass spectrometrySLAS Discov.25(9)1064-1071(2020)
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